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Increased Lipocalin 2 level may have important role in thrombotic events in patients with polycythemia vera and essential thrombocythemia.
Rajnics, P; Kellner, Á; Karádi, É; Moizs, M; Bödör, Cs; Király, P A; Marosvári, D; Andrikovics, H; Egyed, M.
Afiliación
  • Rajnics P; Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary. Electronic address: rajnicsp@hotmail.com.
  • Kellner Á; Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary.
  • Karádi É; Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary.
  • Moizs M; Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary.
  • Bödör C; MTA-SE Lendulet Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University.
  • Király PA; MTA-SE Lendulet Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University.
  • Marosvári D; MTA-SE Lendulet Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University.
  • Andrikovics H; Hungarian National Blood Transfusion Service, Laboratory of Molecular Diagnostics, Budapest, Hungary.
  • Egyed M; Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary.
Leuk Res ; 48: 101-6, 2016 09.
Article en En | MEDLINE | ID: mdl-27161323
The aim of our study was to evaluate the possible effect of lipocalin 2 on thrombotic events in polycythemia vera and essential thrombocythemia patients. The samples of 89 patients were collected and RNA based method was used to evaluate the relative gene expression level of lipocalin 2. 74 samples were available for evaluation. Drawing a cut off point at level 30 relative expression rate, 13 patients with elevated lipocalin 2 expression had thrombotic events during the course of their disease. Based on these data high lipocalin 2 expression level seems to have strong positive predictive value on thrombotic events in patients with polycythemia vera and essential thrombocythemia. Lipocalin 2 may be useful in thrombotic risk stratification in these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Policitemia Vera / Trombosis / Lipocalina 2 / Trombocitemia Esencial Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Res Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Policitemia Vera / Trombosis / Lipocalina 2 / Trombocitemia Esencial Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Res Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido