Your browser doesn't support javascript.
loading
Isoniazid hair concentrations in children with tuberculosis: a proof of concept study.
Mave, V; Chandanwale, A; Kinikar, A; Khadse, S; Kagal, A; Gupte, N; Suryavanshi, N; Nimkar, S; Koli, H; Khwaja, S; Bharadwaj, R; Joshi, S; Horng, H; Benet, L Z; Ramachandran, G; Dooley, K E; Gupta, A; Gandhi, M.
Afiliación
  • Mave V; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Chandanwale A; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
  • Kinikar A; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
  • Khadse S; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
  • Kagal A; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
  • Gupte N; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Suryavanshi N; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
  • Nimkar S; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
  • Koli H; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
  • Khwaja S; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
  • Bharadwaj R; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
  • Joshi S; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
  • Horng H; University of California, San Francisco, California, USA.
  • Benet LZ; University of California, San Francisco, California, USA.
  • Ramachandran G; National Institute of Research in Tuberculosis, Chennai, India.
  • Dooley KE; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Gupta A; Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Gandhi M; University of California, San Francisco, California, USA.
Int J Tuberc Lung Dis ; 20(6): 844-7, 2016 06.
Article en En | MEDLINE | ID: mdl-27155191
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on a thrice-weekly treatment regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. INH concentrations in hair were measured using liquid chromatography-tandem mass spectrometry at 1, 2, 4 and 6 months after initiating anti-tuberculosis treatment. We found that INH hair concentrations in all children on thrice-weekly INH were detectable and displayed variability across a dynamic range.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Cabello / Isoniazida / Antituberculosos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Int J Tuberc Lung Dis Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Cabello / Isoniazida / Antituberculosos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Int J Tuberc Lung Dis Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia