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Immunohistochemical evaluation of p16 expression in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions.
Smith, Emily H; Lowe, Lori; Harms, Paul W; Fullen, Douglas R; Chan, May P.
Afiliación
  • Smith EH; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
  • Lowe L; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
  • Harms PW; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Fullen DR; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
  • Chan MP; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
J Cutan Pathol ; 43(8): 671-8, 2016 Aug.
Article en En | MEDLINE | ID: mdl-27152444
BACKGROUND: Expression of p16 is frequently evaluated in melanocytic lesions. Expression of p16 in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions has not been well characterized. METHODS: We evaluated p16 expression in a cohort of histiocytic (reticulohistiocytoma, Langerhans cell histiocytosis, xanthogranuloma, Rosai Dorfman disease and xanthoma), fibrohistiocytic (dermatofibroma, epithelioid fibrous histiocytoma and dermatofibrosarcoma protuberans) and undifferentiated (atypical fibroxanthoma and pleomorphic undifferentiated sarcoma) lesions. A group of melanocytic lesions (Spitz nevus, ordinary nevus, spitzoid melanoma and non-spitzoid melanoma) were also evaluated as reference. Each case was scored by the proportion of p16-positive cells and by staining intensity. RESULTS: Immunoreactivity for p16 was found in almost all histiocytic (28/30, 93%) and fibrohistiocytic (22/24, 92%) lesions. About half of the undifferentiated lesions also exhibited p16 staining (9/17, 53%). Most of the melanocytic cases examined in this study expressed p16. A wide range of staining intensity and proportion of p16-positive cells was observed in most groups. CONCLUSION: Expression of p16 is common, albeit variable in proportion and intensity, amongst a wide variety of cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions. Further studies are required to determine if p16 expression is useful in distinguishing benign from malignant neoplasms of these types.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Biomarcadores de Tumor / Inhibidor p18 de las Quinasas Dependientes de la Ciclina Límite: Adult / Female / Humans Idioma: En Revista: J Cutan Pathol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Biomarcadores de Tumor / Inhibidor p18 de las Quinasas Dependientes de la Ciclina Límite: Adult / Female / Humans Idioma: En Revista: J Cutan Pathol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos