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Comparing Charge Transport in Oligonucleotides: RNA:DNA Hybrids and DNA Duplexes.
Li, Yuanhui; Artés, Juan M; Qi, Jianqing; Morelan, Ian A; Feldstein, Paul; Anantram, M P; Hihath, Joshua.
Afiliación
  • Li Y; Electrical and Computer Engineering Department, University of California Davis , Davis, California 95616, United States.
  • Artés JM; Electrical and Computer Engineering Department, University of California Davis , Davis, California 95616, United States.
  • Qi J; Department of Electrical Engineering, University of Washington , Seattle, Washington 98195, United States.
  • Morelan IA; Department of Plant Pathology, University of California Davis , Davis, California 95616, United States.
  • Feldstein P; Department of Plant Pathology, University of California Davis , Davis, California 95616, United States.
  • Anantram MP; Department of Electrical Engineering, University of Washington , Seattle, Washington 98195, United States.
  • Hihath J; Electrical and Computer Engineering Department, University of California Davis , Davis, California 95616, United States.
J Phys Chem Lett ; 7(10): 1888-94, 2016 05 19.
Article en En | MEDLINE | ID: mdl-27145167
Understanding the electronic properties of oligonucleotide systems is important for applications in nanotechnology, biology, and sensing systems. Here the charge-transport properties of guanine-rich RNA:DNA hybrids are compared to double-stranded DNA (dsDNA) duplexes with identical sequences. The conductance of the RNA:DNA hybrids is ∼10 times higher than the equivalent dsDNA, and conformational differences are determined to be the primary reason for this difference. The conductance of the RNA:DNA hybrids is also found to decrease more rapidly than dsDNA when the length is increased. Ab initio electronic structure and Green's function-based density of states calculations demonstrate that these differences arise because the energy levels are more spatially distributed in the RNA:DNA hybrid but that the number of accessible hopping sites is smaller. These combination results indicate that a simple hopping model that treats each individual guanine as a hopping site is insufficient to explain both a higher conductance and ß value for RNA:DNA hybrids, and larger delocalization lengths must be considered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligonucleótidos / ADN / ARN Idioma: En Revista: J Phys Chem Lett Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligonucleótidos / ADN / ARN Idioma: En Revista: J Phys Chem Lett Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos