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Single fiber EMG as a prognostic tool in myasthenia gravis.
Baruca, Mateja; Leonardis, Lea; Podnar, Simon; Hojs-Fabjan, Tanja; Grad, Anton; Jerin, Ales; Blagus, Rok; Sega-Jazbec, Sasa.
Afiliación
  • Baruca M; University Medical Centre Ljubljana, Department of Neurology, Zaloska cesta 2,1000, Ljubljana, Slovenia.
  • Leonardis L; University Medical Centre Ljubljana, Institute of Clinical Neurophysiology, Ljubljana, Slovenia.
  • Podnar S; University Medical Centre Ljubljana, Institute of Clinical Neurophysiology, Ljubljana, Slovenia.
  • Hojs-Fabjan T; University Medical Centre Maribor, Department of Neurology, Maribor.
  • Grad A; General Hospital of Isola, Isola, Slovenia.
  • Jerin A; University Medical Centre Ljubljana, Clinical institute of Clinical Chemistry and biochemistry, Ljubljana, Slovenia.
  • Blagus R; Institute for Biostatistics and Medical Informatics, University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia.
  • Sega-Jazbec S; University Medical Centre Ljubljana, Department of Neurology, Zaloska cesta 2,1000, Ljubljana, Slovenia.
Muscle Nerve ; 54(6): 1034-1040, 2016 12.
Article en En | MEDLINE | ID: mdl-27144873
INTRODUCTION: Single fiber electromyography (SFEMG) is the most sensitive diagnostic tool for diagnosis of myasthenia gravis (MG). Its prognostic value is not known. METHODS: We retrospectively analyzed the clinical course of 232 MG patients who presented with only mild symptoms and had SFEMG of the orbicularis oculi muscle. We correlated their SFEMG results with the severity of their later clinical course. RESULTS: During the observation period 39 patients (17%) developed severe disease exacerbations, and 193 (83%) remained stable. Patients with severe disease exacerbation had a significantly higher mean jitter value (P < 0.0001), a greater percentage of fibers with increased jitter (P < 0.0001), and/or impulse blocking (P < 0.0001) on SFEMG. CONCLUSIONS: The extent of the SFEMG abnormalities in this study correlated with the later clinical course of MG. Muscle Nerve 54: 1034-1040, 2016.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Músculo Esquelético / Fibras Musculares Esqueléticas / Potenciales Evocados Motores / Electromiografía / Miastenia Gravis Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Año: 2016 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Músculo Esquelético / Fibras Musculares Esqueléticas / Potenciales Evocados Motores / Electromiografía / Miastenia Gravis Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Año: 2016 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Estados Unidos