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Genetic micro-heterogeneity of Leishmania major in emerging foci of zoonotic cutaneous leishmaniasis in Tunisia.
Attia, Hanene; Sghaier, Rabiaa M; Gelanew, Tesfaye; Bali, Aymen; Schweynoch, Carola; Guerfali, Fatma Z; Mkannez, Ghada; Chlif, Sadok; Belhaj-Hamida, Nabil; Dellagi, Koussay; Schönian, Gabriele; Laouini, Dhafer.
Afiliación
  • Attia H; Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère 1002, Tunisia; Université Tunis El Manar, Tunis 1068, Tunisia.
  • Sghaier RM; Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère 1002, Tunisia; Université Tunis El Manar, Tunis 1068, Tunisia.
  • Gelanew T; Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Bali A; Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère 1002, Tunisia; Université Tunis El Manar, Tunis 1068, Tunisia.
  • Schweynoch C; Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Guerfali FZ; Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère 1002, Tunisia; Université Tunis El Manar, Tunis 1068, Tunisia.
  • Mkannez G; Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère 1002, Tunisia; Université Tunis El Manar, Tunis 1068, Tunisia.
  • Chlif S; Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère 1002, Tunisia; Université Tunis El Manar, Tunis 1068, Tunisia; Institut Pasteur de Tunis, Service of Medical Epidemiology, Tunis-Belvédère 1002, Tunisia.
  • Belhaj-Hamida N; Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère 1002, Tunisia; Université Tunis El Manar, Tunis 1068, Tunisia; Institut Pasteur de Tunis, Service of Medical Epidemiology, Tunis-Belvédère 1002, Tunisia.
  • Dellagi K; Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère 1002, Tunisia; Université Tunis El Manar, Tunis 1068, Tunisia.
  • Schönian G; Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Laouini D; Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère 1002, Tunisia; Université Tunis El Manar, Tunis 1068, Tunisia. Electronic address: dhafer_l@yahoo.ca.
Infect Genet Evol ; 43: 179-85, 2016 09.
Article en En | MEDLINE | ID: mdl-27137082
Tunisia is endemic for zoonotic cutaneous leishmaniasis (ZCL), a parasitic disease caused by Leishmania (L.) major. ZCL displays a wide clinical polymorphism, with severe forms present more frequently in emerging foci where naive populations are dominant. In this study, we applied the multi-locus microsatellite typing (MLMT) using ten highly informative and discriminative markers to investigate the genetic structure of 35 Tunisian Leishmania (L.) major isolates collected from patients living in five different foci of Central Tunisia (two old and three emerging foci). Phylogenetic reconstructions based on genetic distances showed that nine of the ten tested loci were homogeneous in all isolates with homozygous alleles, whereas one locus (71AT) had a 58/64-bp bi-allelic profile with an allele linked to emerging foci. Promastigote-stage parasites with the 58-bp allele tend to be more resistant to in vitro complement lysis. These results, which stress the geographical dependence of the genetic micro-heterogeneity, may improve our understanding of the ZCL epidemiology and clinical outcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / ADN Protozoario / Leishmaniasis Cutánea / Leishmania major / Genoma de Protozoos / Enfermedades Endémicas / Estadios del Ciclo de Vida Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2016 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / ADN Protozoario / Leishmaniasis Cutánea / Leishmania major / Genoma de Protozoos / Enfermedades Endémicas / Estadios del Ciclo de Vida Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2016 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Países Bajos