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Prognostic value of Ki67 in localized prostate carcinoma: a multi-institutional study of >1000 prostatectomies.
Tretiakova, M S; Wei, W; Boyer, H D; Newcomb, L F; Hawley, S; Auman, H; Vakar-Lopez, F; McKenney, J K; Fazli, L; Simko, J; Troyer, D A; Hurtado-Coll, A; Thompson, I M; Carroll, P R; Ellis, W J; Gleave, M E; Nelson, P S; Lin, D W; True, L D; Feng, Z; Brooks, J D.
Afiliación
  • Tretiakova MS; University of Washington, Seattle, WA, USA.
  • Wei W; MD Anderson Cancer Center, Houston, TX, USA.
  • Boyer HD; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Newcomb LF; University of Washington, Seattle, WA, USA.
  • Hawley S; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Auman H; Canary Foundation, Redwood City, CA, USA.
  • Vakar-Lopez F; Canary Foundation, Redwood City, CA, USA.
  • McKenney JK; University of Washington, Seattle, WA, USA.
  • Fazli L; Cleveland Clinic, Cleveland, OH, USA.
  • Simko J; University of British Columbia, Vancouver, BC, Canada.
  • Troyer DA; University of California at San Francisco, CA, USA.
  • Hurtado-Coll A; Eastern Virginia Medical School, Norfolk, VA, USA.
  • Thompson IM; University of British Columbia, Vancouver, BC, Canada.
  • Carroll PR; University of Texas Health Sciences Center at San Antonio, TX, USA.
  • Ellis WJ; University of California at San Francisco, CA, USA.
  • Gleave ME; University of Washington, Seattle, WA, USA.
  • Nelson PS; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Lin DW; University of British Columbia, Vancouver, BC, Canada.
  • True LD; University of Washington, Seattle, WA, USA.
  • Feng Z; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Brooks JD; University of Washington, Seattle, WA, USA.
Prostate Cancer Prostatic Dis ; 19(3): 264-70, 2016 09.
Article en En | MEDLINE | ID: mdl-27136741
BACKGROUND: Expanding interest in and use of active surveillance for early state prostate cancer (PC) has increased need for prognostic biomarkers. Using a multi-institutional tissue microarray resource including over 1000 radical prostatectomy samples, we sought to correlate Ki67 expression captured by an automated image analysis system with clinicopathological features and validate its utility as a clinical grade test in predicting cancer-specific outcomes. METHODS: After immunostaining, the Ki67 proliferation index (PI) of tumor areas of each core (three cancer cores/case) was analyzed using a nuclear quantification algorithm (Aperio). We assessed whether Ki67 PI was associated with clinicopathological factors and recurrence-free survival (RFS) including biochemical recurrence, metastasis or PC death (7-year median follow-up). RESULTS: In 1004 PCs (∼4000 tissue cores) Ki67 PI showed significantly higher inter-tumor (0.68) than intra-tumor variation (0.39). Ki67 PI was associated with stage (P<0.0001), seminal vesicle invasion (SVI, P=0.02), extracapsular extension (ECE, P<0.0001) and Gleason score (GS, P<0.0001). Ki67 PI as a continuous variable significantly correlated with recurrence-free, overall and disease-specific survival by multivariable Cox proportional hazard model (hazards ratio (HR)=1.04-1.1, P=0.02-0.0008). High Ki67 score (defined as ⩾5%) was significantly associated with worse RFS (HR=1.47, P=0.0007) and worse overall survival (HR=2.03, P=0.03). CONCLUSIONS: In localized PC treated by radical prostatectomy, higher Ki67 PI assessed using a clinical grade automated algorithm is strongly associated with a higher GS, stage, SVI and ECE and greater probability of recurrence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Antígeno Ki-67 Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans / Male Idioma: En Revista: Prostate Cancer Prostatic Dis Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS / UROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Antígeno Ki-67 Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans / Male Idioma: En Revista: Prostate Cancer Prostatic Dis Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS / UROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido