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Environmental stress cracking performance of polyether and PDMS-based polyurethanes in an in vitro oxidation model.
Gallagher, Genevieve; Padsalgikar, Ajay; Tkatchouk, Ekaterina; Jenney, Chris; Iacob, Ciprian; Runt, James.
Afiliación
  • Gallagher G; St. Jude Medical, St. Paul, MN.
  • Padsalgikar A; St. Jude Medical, Rogers, MN.
  • Tkatchouk E; St. Jude Medical, Sylmar, CA.
  • Jenney C; St. Jude Medical, Sylmar, CA.
  • Iacob C; Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA.
  • Runt J; Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA.
J Biomed Mater Res B Appl Biomater ; 105(6): 1544-1558, 2017 08.
Article en En | MEDLINE | ID: mdl-27125763
Environmental stress cracking (ESC) was replicated in vitro on Optim™ (OPT) insulation, a polydimethylsiloxane-based polyurethane utilized clinically in cardiac leads, using a Zhao-type oxidation model. OPT performance was compared to that of two industry standard polyether urethanes: Pellethane® 80A (P80A), and Pellethane® 55D (P55D). Clinically relevant specimen configurations and strain states were utilized: low-voltage cardiac lead segments were held in a U-shape by placing them inside of vials. To study whether aging conditions impacted ESC formation, half of the samples were subjected to a pretreatment in human plasma for 7 days at 37°C; all samples were then aged in oxidative solutions containing 0.9% NaCl, 20% H2 O2 , and either 0 or 0.1M CoCl2 , with or without glass wool for 72 days at 37°C. Visual and SEM inspection revealed significant surface cracking consistent with ESC on all P80A and P55D samples. Sixteen of twenty P80A and 10/20 P55D samples also exhibited breaches. Seven of 20 OPT samples exhibited shallow surface cracking consistent with ESC. ATR-FTIR confirmed surface changes consistent with oxidation for all materials. The number average molecular weight decreased an average of 31% for OPT, 86% for P80A, and 56% for P55D samples. OPT outperformed P80A and P55D in this Zhao-type in vitro ESC model. An aging solution of 0.9% NaCl, 20% H2 O2 , and 0.1M CoCl2 , with glass wool provided the best combination of ESC replication and ease of use. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1544-1558, 2017.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliuretanos / Estrés Mecánico / Cloruro de Sodio / Dimetilpolisiloxanos / Peróxido de Hidrógeno Idioma: En Revista: J Biomed Mater Res B Appl Biomater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliuretanos / Estrés Mecánico / Cloruro de Sodio / Dimetilpolisiloxanos / Peróxido de Hidrógeno Idioma: En Revista: J Biomed Mater Res B Appl Biomater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos