Trouble in transitioning: activation of zygotic transcription can lead to DNA breakage and genome instability.

Butuci, Melina; Wong, Matthew M; Michael, W Matthew

Butuci, Melina; Wong, Matthew M; Michael, W Matthew.

Afiliación

Butuci M; Molecular and Computational Biology Section; Department of Biological Sciences; University of Southern California ; Los Angeles, CA USA.
Wong MM; Molecular and Computational Biology Section; Department of Biological Sciences; University of Southern California ; Los Angeles, CA USA.
Michael WM; Molecular and Computational Biology Section; Department of Biological Sciences; University of Southern California ; Los Angeles, CA USA.

Worm ; 4(4): e1115946, 2015.

Article en En | MEDLINE | ID: mdl-27123372

RESUMEN

Recent work from our laboratory has identified zygotic genome activation as a source of intrinsic DNA damage during germline development in C. elegans. More specifically, we have found that the primordial germ cells Z2 and Z3 experience DNA damage and damage checkpoint activation shortly after RNA polymerase II is activated by a nutrient-dependent signal in L1 stage animals. In this Commentary we review these data, put them into context with other examples of programmed DNA double-strand breaks (DSBs) during gene activation, and speculate as to how a DSB would facilitate signal-dependent activation of gene expression.

Palabras clave

C. elegans; DNA damage; TOP-2; X chromosome; Z2/Z3; primordial germ cells (PGCs); transcription

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Worm Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos

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