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Assessing blood platelets as RNA biomarker source for prostate cancer.
Hänze, Jörg; Jakubowski, Peter; Heers, Hendrik; Hegele, Axel; Timmesfeld, Nina; Hofmann, Rainer; Olbert, Peter J.
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  • Hänze J; a Department of Urology and Pediatric Urology, Philipps- University Marburg , Marburg , Germany ;
  • Jakubowski P; a Department of Urology and Pediatric Urology, Philipps- University Marburg , Marburg , Germany ;
  • Heers H; a Department of Urology and Pediatric Urology, Philipps- University Marburg , Marburg , Germany ;
  • Hegele A; a Department of Urology and Pediatric Urology, Philipps- University Marburg , Marburg , Germany ;
  • Timmesfeld N; b Institute for Medical Biometry and Epidemiology, Philipps-University Marburg , Marburg , Germany.
  • Hofmann R; a Department of Urology and Pediatric Urology, Philipps- University Marburg , Marburg , Germany ;
  • Olbert PJ; a Department of Urology and Pediatric Urology, Philipps- University Marburg , Marburg , Germany ;
Biomarkers ; 21(7): 653-9, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27121394
CONTEXT: Blood platelets may offer as RNA biomarker source for cancer as recently described for an oncogenic transcript in glioma patients and for PCA3 in prostate cancer (PCa) patients. OBJECTIVE: Here, we elaborated on this aspect for PCa. MATERIALS AND METHODS: PCA3 and other PCa-associated RNA markers were measured in platelets of PCa patients (cases) and healthy subjects (controls) in comparison to PCa cell lines by relative quantitative RT-PCR. RESULTS: The RNA markers displayed heterogeneous expression patterns in cell lines and platelets, however, without significant differences between cases and controls. DISCUSSION AND CONCLUSION: The data do not support platelets as a profitable RNA source for early detection of PCa. Nonetheless, certain PCa-derived RNA markers in platelets may merit further investigation as potential prognostic biomarkers for PCa.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Plaquetas / ARN / Biomarcadores de Tumor Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Humans / Male Idioma: En Revista: Biomarkers Asunto de la revista: BIOQUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Plaquetas / ARN / Biomarcadores de Tumor Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Humans / Male Idioma: En Revista: Biomarkers Asunto de la revista: BIOQUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido