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Risk factors for recurrence in patients with papillary thyroid carcinoma undergoing modified radical neck dissection.
Lee, Y M; Sung, T Y; Kim, W B; Chung, K W; Yoon, J H; Hong, S J.
Afiliación
  • Lee YM; Departments of Surgery, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.
  • Sung TY; Departments of Surgery, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.
  • Kim WB; Departments of Internal Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.
  • Chung KW; Departments of Surgery, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.
  • Yoon JH; Departments of Surgery, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.
  • Hong SJ; Departments of Surgery, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.
Br J Surg ; 103(8): 1020-5, 2016 Jul.
Article en En | MEDLINE | ID: mdl-27121346
BACKGROUND: This study evaluated the impact of lymph node-related factors on the risk of and site of recurrence in patients who had papillary thyroid carcinoma with lymph node metastasis in the lateral compartment (classified as pN1b). METHODS: Patients underwent total thyroidectomy with unilateral modified radical neck dissection for classical papillary thyroid carcinoma. Risk factors for recurrence were evaluated according to the pattern of recurrence. RESULTS: A total of 324 patients were included in the study. The median follow-up was 63 (range 14-181) months. Recurrence was detected in 47 patients (14·5 per cent). In the multivariable analysis, a maximum diameter of metastatic lymph nodes larger than 2·0 cm (hazard ratio (HR) 1·15, 95 per cent c.i. 1·06 to 1·25; P = 0·033) and a central compartment metastatic lymph node ratio of more than 0·42 (HR 3·35, 1·65 to 6·79; P < 0·001) were identified as independent risk factors for locoregional recurrence. Age 45 years or older (HR 5·69, 1·24 to 26·12; P = 0·025) and extranodal extension of metastasis (HR 12·71, 1·64 to 98·25; P = 0·015) were risk factors for distant metastasis. In subgroup analysis of locoregional recurrence, several lymph node-related factors affected the risk of recurrence according to the specific site of metastasis. CONCLUSION: Lymph node-related factors are of importance for the risk of recurrence in patients with classical papillary thyroid carcinoma classified as pN1b.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disección del Cuello / Neoplasias de la Tiroides / Carcinoma Papilar / Recurrencia Local de Neoplasia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Br J Surg Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disección del Cuello / Neoplasias de la Tiroides / Carcinoma Papilar / Recurrencia Local de Neoplasia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Br J Surg Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido