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HIV Infection and Carotid Artery Intima-media Thickness: Pooled Analyses Across 5 Cohorts of the NHLBI HIV-CVD Collaborative.
Hanna, David B; Guo, Mengye; Buzková, Petra; Miller, Tracie L; Post, Wendy S; Stein, James H; Currier, Judith S; Kronmal, Richard A; Freiberg, Matthew S; Bennett, Siiri N; Shikuma, Cecilia M; Anastos, Kathryn; Li, Yanjie; Tracy, Russell P; Hodis, Howard N; Delaney, Joseph A; Kaplan, Robert C.
Afiliación
  • Hanna DB; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
  • Guo M; Department of Biostatistics.
  • Buzková P; Department of Biostatistics.
  • Miller TL; Department of Pediatrics, University of Miami, Florida.
  • Post WS; Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
  • Stein JH; Department of Medicine, University of Wisconsin at Madison.
  • Currier JS; Department of Medicine, University of California.
  • Kronmal RA; Department of Biostatistics.
  • Freiberg MS; Department of Medicine, Vanderbilt University, Nashville, Tennessee.
  • Bennett SN; Department of Biostatistics.
  • Shikuma CM; Department of Medicine, University of Hawaii, Honolulu.
  • Anastos K; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
  • Li Y; Department of Medicine, University of Southern California, Los Angeles.
  • Tracy RP; Department of Pathology, University of Vermont, Colchester.
  • Hodis HN; Department of Medicine, University of Southern California, Los Angeles.
  • Delaney JA; Department of Epidemiology, University of Washington, Seattle.
  • Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
Clin Infect Dis ; 63(2): 249-56, 2016 07 15.
Article en En | MEDLINE | ID: mdl-27118787
BACKGROUND: Age and human immunodeficiency virus (HIV) treatment may affect the association of HIV infection with atherosclerosis. METHODS: We used identical carotid artery B-mode ultrasonographic methods in 5 cohorts participating in the National Heart, Lung, and Blood Institute HIV-CVD Collaborative to measure intima-media thickness of the right far wall of the common carotid artery (CCA-IMT) and carotid artery bifurcation (BIF-IMT) between 2010 and 2013. Participants aged 6-75 years were either HIV infected or uninfected. Linear regression assessed associations of CCA-IMT and BIF-IMT with HIV infection and cardiovascular disease risk factors, within age and HIV treatment groups. Adjustment variables included sex, race/ethnicity, smoking, height, weight, and use of antihypertensive and lipid-lowering drugs. RESULTS: We studied 867 HIV-infected and 338 HIV-uninfected male and 696 HIV-infected and 246 HIV-uninfected female participants. Among both middle-aged (30-49 years) and older adults (50-75 years), HIV-infected participants had CCA-IMT and BIF-IMT values that were similar to or lower than those in HIV-uninfected participants. In contrast, among those aged 6-29 years, HIV infection was associated with higher CCA-IMT and BIF-IMT values. Among HIV-infected participants, associations of higher systolic blood pressure and lower high-density lipoprotein cholesterol with Carotid artery intima-media thickness strengthened with age. CONCLUSIONS: The effects of HIV on carotid artery structure may differ across the lifespan, with traditional determinants of cardiovascular disease burden playing a larger role and HIV playing a lesser role in older adults than in young adults and children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Arteria Carótida Común / Aterosclerosis / Grosor Intima-Media Carotídeo Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Arteria Carótida Común / Aterosclerosis / Grosor Intima-Media Carotídeo Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos