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Patients With Coronary Endothelial Dysfunction Have Impaired Cholesterol Efflux Capacity and Reduced HDL Particle Concentration.
Monette, Jeffrey S; Hutchins, Patrick M; Ronsein, Graziella E; Wimberger, Jake; Irwin, Angela D; Tang, Chongren; Sara, Jaskanwal D; Shao, Baohai; Vaisar, Tomas; Lerman, Amir; Heinecke, Jay W.
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  • Monette JS; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.).
  • Hutchins PM; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.).
  • Ronsein GE; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.).
  • Wimberger J; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.).
  • Irwin AD; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.).
  • Tang C; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.).
  • Sara JD; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.).
  • Shao B; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.).
  • Vaisar T; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.).
  • Lerman A; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.).
  • Heinecke JW; From the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle (J.S.M., P.M.H., G.E.R., J.W., A.D.I., C.T., B.S., T.V., J.W.H.); and Division of Cardiovascular Disease, Mayo Clinic, Rochester, MN (J.D.S., A.L.). heinecke@uw.edu.
Circ Res ; 119(1): 83-90, 2016 06 24.
Article en En | MEDLINE | ID: mdl-27114438
RATIONALE: Coronary endothelial dysfunction (ED)-an early marker of atherosclerosis-increases the risk of cardiovascular events. OBJECTIVE: We tested the hypothesis that cholesterol efflux capacity and high-density lipoprotein (HDL) particle concentration predict coronary ED better than HDL-cholesterol (HDL-C). METHODS AND RESULTS: We studied 80 subjects with nonobstructive (<30% stenosis) coronary artery disease. ED was defined as <50% change in coronary blood flow in response to intracoronary infusions of acetylcholine during diagnostic coronary angiography. Cholesterol efflux capacity and HDL particle concentration (HDL-PIMA) were assessed with validated assays. Cholesterol efflux capacity and HDL-PIMA were both strong, inverse predictors of ED (P<0.001 and 0.005, respectively). In contrast, HDL-C and other traditional lipid risk factors did not differ significantly between control and ED subjects. Large HDL particles were markedly decreased in ED subjects (33%; P=0.005). After correction for HDL-C, both efflux capacity and HDL-PIMA remained significant predictors of ED status. HDL-PIMA explained cholesterol efflux capacity more effectively than HDL-C (r=0.54 and 0.36, respectively). The efflux capacities of isolated HDL and serum HDL correlated strongly (r=0.49). CONCLUSIONS: Cholesterol efflux capacity and HDL-PIMA are reduced in subjects with coronary ED, independently of HDL-C. Alterations in HDL-PIMA and HDL itself account for a much larger fraction of the variation in cholesterol efflux capacity than does HDL-C. A selective decrease in large HDL particles may contribute to impaired cholesterol efflux capacity in ED subjects. These observations support a role for HDL size, concentration, and function as markers-and perhaps mediators-of coronary atherosclerosis in humans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Endotelio Vascular / HDL-Colesterol Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Circ Res Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Endotelio Vascular / HDL-Colesterol Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Circ Res Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos