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The genetic relationship between cannabis and tobacco cigarette use in European- and African-American female twins and siblings.
Agrawal, Arpana; Grant, Julia D; Lynskey, Michael T; Madden, Pamela A F; Heath, Andrew C; Bucholz, Kathleen K; Sartor, Carolyn E.
Afiliación
  • Agrawal A; Washington University School of Medicine, Department of Psychiatry, 660 S. Euclid, CB 8134, Saint Louis, MO 63110, USA. Electronic address: arpana@wustl.edu.
  • Grant JD; Washington University School of Medicine, Department of Psychiatry, 660 S. Euclid, CB 8134, Saint Louis, MO 63110, USA.
  • Lynskey MT; King's College, Department of Addictions, London, UK.
  • Madden PA; Washington University School of Medicine, Department of Psychiatry, 660 S. Euclid, CB 8134, Saint Louis, MO 63110, USA.
  • Heath AC; Washington University School of Medicine, Department of Psychiatry, 660 S. Euclid, CB 8134, Saint Louis, MO 63110, USA.
  • Bucholz KK; Washington University School of Medicine, Department of Psychiatry, 660 S. Euclid, CB 8134, Saint Louis, MO 63110, USA.
  • Sartor CE; Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
Drug Alcohol Depend ; 163: 165-71, 2016 Jun 01.
Article en En | MEDLINE | ID: mdl-27114204
BACKGROUND: Use of cigarettes and cannabis frequently co-occurs. We examine the role of genetic and environmental influences on variation in and covariation between tobacco cigarette and cannabis use across European-American (EA) and African-American (AA) women. METHODS: Data on lifetime cannabis and cigarette use were drawn from interviews of 956 AA and 3557 EA young adult female twins and non-twin same sex female full siblings. Twin modeling was used to decompose variance in and covariance between cigarette and cannabis use into additive genetic, shared, special twin and non-shared environmental sources. RESULTS: Cigarette use was more common in EAs (75.3%, 95% C.I. 73.8-76.7%) than AAs (64.2%, 95% C.I. 61.2-67.2%) while cannabis use was marginally more commonly reported by AAs (55.5%, 95% C.I. 52.5-58.8%) than EAs (52.4%, 95% C.I. 50.7-54.0%). Additive genetic factors were responsible for 43-66% of the variance in cigarette and cannabis use. Broad shared environmental factors (shared+special twin) played a more significant role in EA (23-29%) than AA (2-15%) women. In AA women, the influence of non-shared environment was more pronounced (42-45% vs. 11-19% in EA women). There was strong evidence for the same familial influences underlying use of both substances (rA=0.82-0.89; rC+T=0.70-0.75). Non-shared environmental factors were also correlated but less so (rE=0.48-0.66). No racial/ethnic differences were apparent in these sources of covariation. CONCLUSION: Heritability of cigarette and cannabis use is comparable across racial/ethnic groups. Differences in the contribution of shared and non-shared environmental influences indicate that different factors may shape substance use in EA and AA women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gemelos / Negro o Afroamericano / Fumar Marihuana / Fumar / Hermanos / Población Blanca Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Female / Humans Idioma: En Revista: Drug Alcohol Depend Año: 2016 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gemelos / Negro o Afroamericano / Fumar Marihuana / Fumar / Hermanos / Población Blanca Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Female / Humans Idioma: En Revista: Drug Alcohol Depend Año: 2016 Tipo del documento: Article Pais de publicación: Irlanda