Your browser doesn't support javascript.
loading
Genetic and environmental modulation of neurodevelopmental disorders: Translational insights from labs to beds.
Homberg, Judith R; Kyzar, Evan J; Scattoni, Maria Luisa; Norton, William H; Pittman, Julian; Gaikwad, Siddharth; Nguyen, Michael; Poudel, Manoj K; Ullmann, Jeremy F P; Diamond, David M; Kaluyeva, Aleksandra A; Parker, Matthew O; Brown, Richard E; Song, Cai; Gainetdinov, Raul R; Gottesman, Irving I; Kalueff, Allan V.
Afiliación
  • Homberg JR; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands.
  • Kyzar EJ; Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
  • Scattoni ML; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy.
  • Norton WH; Department of Biology, University of Leicester, Leicester, UK.
  • Pittman J; Department of Biological and Environmental Sciences, Troy University, Troy, AL, USA.
  • Gaikwad S; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
  • Nguyen M; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA; New York University School of Medicine, NY, NY, USA.
  • Poudel MK; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
  • Ullmann JF; Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA.
  • Diamond DM; Department of Psychology, University of South Florida, Tampa, FL, USA; J.A. Haley Veterans Hospital, Research and Development Service, Tampa, FL, USA.
  • Kaluyeva AA; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
  • Parker MO; School of Health Sciences and Social Work, University of Portsmouth, Portsmouth, UK.
  • Brown RE; Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Song C; Research Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China; Graduate Institute of Neural and Cognitive Sciences, China Medical University Hospital, Taichung, Taiwan.
  • Gainetdinov RR; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Skolkovo Institute of Science and Technology, Skolkovo, Moscow Region, Russia.
  • Gottesman II; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
  • Kalueff AV; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia. Electronic address: avkalueff@gmail.com.
Brain Res Bull ; 125: 79-91, 2016 07.
Article en En | MEDLINE | ID: mdl-27113433
Neurodevelopmental disorders (NDDs) are a heterogeneous group of prevalent neuropsychiatric illnesses with various degrees of social, cognitive, motor, language and affective deficits. NDDs are caused by aberrant brain development due to genetic and environmental perturbations. Common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Genetic and epigenetic/environmental factors play a key role in these NDDs with significant societal impact. Given the lack of their efficient therapies, it is important to gain further translational insights into the pathobiology of NDDs. To address these challenges, the International Stress and Behavior Society (ISBS) has established the Strategic Task Force on NDDs. Summarizing the Panel's findings, here we discuss the neurobiological mechanisms of selected common NDDs and a wider NDD+ spectrum of associated neuropsychiatric disorders with developmental trajectories. We also outline the utility of existing preclinical (animal) models for building translational and cross-diagnostic bridges to improve our understanding of various NDDs.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Ambiente / Investigación Biomédica Traslacional / Trastornos del Neurodesarrollo Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Brain Res Bull Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Ambiente / Investigación Biomédica Traslacional / Trastornos del Neurodesarrollo Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Brain Res Bull Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos