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Preliminary report of the (13)C-mixed triglyceride breath test to assess timing of pancreatic enzyme replacement therapy in children with cystic fibrosis.
van der Haak, Natalie; Boase, Julia; Davidson, Geoffrey; Butler, Ross; Miller, Michelle; Kaambwa, Billingsley; Kritas, Stamatiki.
Afiliación
  • van der Haak N; Department of Nutrition, Women's and Children's Hospital, North Adelaide, South Australia, Australia. Electronic address: natalie.vanderhaak@sa.gov.au.
  • Boase J; Department of Nutrition, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
  • Davidson G; Department of Gastroenterology, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
  • Butler R; Department of Gastroenterology, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
  • Miller M; Nutrition and Dietetics, School of Health Sciences, Faculty of Medicine, Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.
  • Kaambwa B; Flinders Health Economics Group, School of Medicine, Flinders University, Adelaide, Australia.
  • Kritas S; Department of Gastroenterology, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
J Cyst Fibros ; 15(5): 669-74, 2016 09.
Article en En | MEDLINE | ID: mdl-27102891
BACKGROUND: Despite guidelines suggesting pancreatic enzyme replacement therapy (PERT) should be taken before or during a meal, it is currently unknown whether this has benefits over administration after a meal in individuals with cystic fibrosis (CF). METHODS: 18 children with pancreatic insufficient CF were randomised to two (13)C-mixed triglyceride ((13)C-MTG) breath tests to assess lipase activity with PERT administered 10min before and 10min after a meal. Results were expressed as percentage cumulative dose recovered (PCDR) of (13)CO2 and were compared with established values in healthy subjects. Gastric half emptying time (T½) was also assessed by a (13)C-octanoate breath test. RESULTS: There was no difference in mean PCDR of (13)CO2 between taking PERT before versus after the meal (p=0.68). Eleven subjects had a greater PCDR when PERT was taken before and 7 when PERT was taken after the meal. 6/8 subjects (75%) with a lower than normal PCDR at one time point normalised PCDR when PERT timing was changed. When PERT was taken after the meal, PCDR was higher in normal vs. fast T½ (p=0.04). CONCLUSIONS: Changing PERT timing can result in normalised lipase activity. Gastric emptying rate may influence optimal timing of PERT. Clinical Trial Registration Number - This study was undertaken prior to the registration process being a commonly required practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Triglicéridos / Pancrelipasa / Fibrosis Quística / Terapia de Reemplazo Enzimático / Lipasa Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Cyst Fibros Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Triglicéridos / Pancrelipasa / Fibrosis Quística / Terapia de Reemplazo Enzimático / Lipasa Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Cyst Fibros Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos