Rapamycin inhibits epithelial-to-mesenchymal transition of peritoneal mesothelium cells through regulation of Rho GTPases.

Xiang, Shilong; Li, Meng; Xie, Xishao; Xie, Zhoutao; Zhou, Qin; Tian, Yuanshi; Lin, Weiqiang; Zhang, Xiaohui; Jiang, Hong; Shou, Zhangfei; Chen, Jianghua

Xiang, Shilong; Li, Meng; Xie, Xishao; Xie, Zhoutao; Zhou, Qin; Tian, Yuanshi; Lin, Weiqiang; Zhang, Xiaohui; Jiang, Hong; Shou, Zhangfei; Chen, Jianghua.

Afiliación

Xiang S; Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Li M; Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xie X; Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xie Z; Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhou Q; Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Tian Y; Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Lin W; Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhang X; Institute of Translational Medicine, Zhejiang University, Hangzhou, China.
Jiang H; Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Shou Z; Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Chen J; Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

FEBS J ; 283(12): 2309-25, 2016 06.

Article en En | MEDLINE | ID: mdl-27093550

Asunto(s)

Fibrosis Peritoneal/tratamiento farmacológico; Sirolimus/administración & dosificación; Proteína de Unión al GTP cdc42/biosíntesis; Proteína de Unión al GTP rac1/biosíntesis; Proteína de Unión al GTP rhoA/biosíntesis; Animales; Modelos Animales de Enfermedad; Transición Epitelial-Mesenquimal/efectos de los fármacos; Epitelio/efectos de los fármacos; Epitelio/patología; Fibronectinas; Regulación de la Expresión Génica/efectos de los fármacos; Glucosa/toxicidad; Humanos; Fibrosis Peritoneal/inducido químicamente; Fibrosis Peritoneal/genética; Peritoneo/efectos de los fármacos; Peritoneo/metabolismo; Peritoneo/patología; Ratas; Proteína de Unión al GTP cdc42/genética; Proteína de Unión al GTP rac1/genética; Proteína de Unión al GTP rhoA/genética

Palabras clave

Rho GTPases; epithelial-mesenchymal transition; high glucose; mesothelial cells; rapamycin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sirolimus / Proteína de Unión al GTP cdc42 / Proteína de Unión al GTP rac1 / Proteína de Unión al GTP rhoA / Fibrosis Peritoneal Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: FEBS J Asunto de la revista: BIOQUIMICA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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