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Inter-Observer Variation in the Pathologic Identification of Extranodal Extension in Nodal Metastasis from Papillary Thyroid Carcinoma.
Du, Eugenie; Wenig, Bruce M; Su, Henry K; Rowe, Meghan E; Haser, Grace C; Asa, Sylvia L; Baloch, Zubair; Faquin, William C; Fellegara, Giovanni; Giordano, Thomas; Ghossein, Ronald; LiVolsi, Virginia A; Lloyd, Ricardo; Mete, Ozgur; Ozbek, Umut; Rosai, Juan; Suster, Saul; Thompson, Lester D; Turk, Andrew T; Urken, Mark L.
Afiliación
  • Du E; 1 Department of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center, Albert Einstein College of Medicine , Bronx, New York.
  • Wenig BM; 2 Department of Pathology, Mount Sinai Beth Israel , New York, New York.
  • Su HK; 3 Thyroid, Head and Neck Cancer (THANC) Foundation , New York, New York.
  • Rowe ME; 3 Thyroid, Head and Neck Cancer (THANC) Foundation , New York, New York.
  • Haser GC; 3 Thyroid, Head and Neck Cancer (THANC) Foundation , New York, New York.
  • Asa SL; 4 Department of Pathology, Laboratory Medicine Program, Toronto General Hospital , Toronto, Canada .
  • Baloch Z; 5 Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania , Philadelphia, Pennsylvania.
  • Faquin WC; 6 Department of Pathology, Massachusetts General Hospital , Boston, Massachusetts.
  • Fellegara G; 7 Centro Consulenze Anatomia Patologica Oncologica, Centro Diagnostico Italiano , Milan, Italy .
  • Giordano T; 8 Department of Pathology, University of Michigan Medical School , Ann Arbor, Michigan.
  • Ghossein R; 9 Department of Pathology, Memorial Sloan-Kettering Cancer Center , New York, New York.
  • LiVolsi VA; 5 Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania , Philadelphia, Pennsylvania.
  • Lloyd R; 10 Department of Pathology and Laboratory Medicine, University of Wisconsin , Madison, Wisconsin.
  • Mete O; 4 Department of Pathology, Laboratory Medicine Program, Toronto General Hospital , Toronto, Canada .
  • Ozbek U; 11 Population Health Science and Policy, Mount Sinai Hospital , New York, New York.
  • Rosai J; 7 Centro Consulenze Anatomia Patologica Oncologica, Centro Diagnostico Italiano , Milan, Italy .
  • Suster S; 12 Department of Pathology, Medical College of Wisconsin , Milwaukee, Wisconsin.
  • Thompson LD; 13 Department of Pathology, Woodland Hills Medical Center , Woodland Hills, California.
  • Turk AT; 14 Department of Pathology, New York-Presbyterian/Columbia , New York, New York.
  • Urken ML; 15 Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Beth Israel , New York, New York.
Thyroid ; 26(6): 816-9, 2016 06.
Article en En | MEDLINE | ID: mdl-27089928
BACKGROUND: Extranodal extension (ENE) in lymph node metastases has been shown to worsen the prognosis of papillary thyroid cancer (PTC). Despite the clinical significance of ENE, there are no stringent criteria for its microscopic diagnosis, and its identification is subject to inter-observer variability. The objective of this study was to determine the level of agreement among expert pathologists in the identification of ENE in PTC cases. METHODS: Eleven expert pathologists from the United States, Italy, and Canada were asked to review 61 scanned slides of representative permanent sections of PTC specimens from Mount Sinai Beth Israel Medical Center in New York. Each slide was evaluated for the presence of ENE. The pathologists were also asked to report the criteria they use to identify ENE. RESULTS: The overall strength of agreement in identifying ENE was only fair (κ = 0.35), and the proportion of observed agreement was 0.68. The proportions of observed agreement for the identification of perinodal structures (fat, nerve, skeletal, and thick-walled vessel involvement) ranged from 0.61 to 0.997. CONCLUSIONS: Overall agreement for the identification of ENE is poor. The lack of agreement results from both variation in pathologists' identification of features and disagreement on the histologic criteria for ENE. This lack of concordance may help explain some of the discordant information regarding prognosis in clinical studies when this feature is identified.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Carcinoma Papilar / Ganglios Linfáticos / Metástasis Linfática Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Thyroid Asunto de la revista: ENDOCRINOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Carcinoma Papilar / Ganglios Linfáticos / Metástasis Linfática Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Thyroid Asunto de la revista: ENDOCRINOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos