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Cytokine responses in birds challenged with the human food-borne pathogen Campylobacter jejuni implies a Th17 response.
Reid, William D K; Close, Andrew J; Humphrey, Suzanne; Chaloner, Gemma; Lacharme-Lora, Lizeth; Rothwell, Lisa; Kaiser, Pete; Williams, Nicola J; Humphrey, Tom J; Wigley, Paul; Rushton, Stephen P.
Afiliación
  • Reid WD; School of Biology , Newcastle University , Ridley Building, Newcastle upon Tyne NE1 7RU , UK.
  • Close AJ; School of Biology , Newcastle University , Ridley Building, Newcastle upon Tyne NE1 7RU , UK.
  • Humphrey S; Department of Infection Biology , Institute of Global Health, University of Liverpool , Leahurst Campus, Neston, Chester CH64 7TE , UK.
  • Chaloner G; Department of Infection Biology , Institute of Global Health, University of Liverpool , Leahurst Campus, Neston, Chester CH64 7TE , UK.
  • Lacharme-Lora L; Department of Infection Biology , Institute of Global Health, University of Liverpool , Leahurst Campus, Neston, Chester CH64 7TE , UK.
  • Rothwell L; The Roslin Institute and Royal (Dick) School of Veterinary Science , University of Edinburgh , Midlothian EH25 9RG , UK.
  • Kaiser P; The Roslin Institute and Royal (Dick) School of Veterinary Science , University of Edinburgh , Midlothian EH25 9RG , UK.
  • Williams NJ; Department of Epidemiology and Population Health , Institute of Global Health, University of Liverpool , Leahurst Campus, Neston, Chester CH64 7TE , UK.
  • Humphrey TJ; College of Medicine , Swansea University , Singleton Park, Swansea SA2 8PP , UK.
  • Wigley P; Department of Infection Biology , Institute of Global Health, University of Liverpool , Leahurst Campus, Neston, Chester CH64 7TE , UK.
  • Rushton SP; School of Biology , Newcastle University , Ridley Building, Newcastle upon Tyne NE1 7RU , UK.
R Soc Open Sci ; 3(3): 150541, 2016 Mar.
Article en En | MEDLINE | ID: mdl-27069644
Development of process orientated understanding of cytokine interactions within the gastrointestinal tract during an immune response to pathogens requires experimentation and statistical modelling. The immune response against pathogen challenge depends on the specific threat to the host. Here, we show that broiler chickens mount a breed-dependent immune response to Campylobacter jejuni infection in the caeca by analysing experimental data using frequentist and Bayesian structural equation models (SEM). SEM provides a framework by which cytokine interdependencies, based on prior knowledge, can be tested. In both breeds important cytokines including pro-inflammatory interleukin (IL)-1ß, , IL-4, IL-17A, interferon (IFN)-γ and anti-inflammatory IL-10 and transforming growth factor (TGF)-ß4 were expressed post-challenge. The SEM revealed a putative regulatory pathway illustrating a T helper (Th)17 response and regulation of IL-10, which is breed-dependent. The prominence of the Th17 pathway indicates the cytokine response aims to limit the invasion or colonization of an extracellular bacterial pathogen but the time-dependent nature of the response differs between breeds.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: R Soc Open Sci Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: R Soc Open Sci Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido