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Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation.
Skuladottir, G V; Cohen, A; Arnar, D O; Hougaard, D M; Torfason, B; Palsson, R; Indridason, O S.
Afiliación
  • Skuladottir GV; Department of Physiology, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
  • Cohen A; Department of Congenital Disorders , Statens Serum Institute , Copenhagen , Denmark.
  • Arnar DO; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Internal Medicine Services, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
  • Hougaard DM; Department of Congenital Disorders , Statens Serum Institute , Copenhagen , Denmark.
  • Torfason B; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Surgical Services, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
  • Palsson R; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Internal Medicine Services, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
  • Indridason OS; Internal Medicine Services , Landspitali - The National University Hospital of Iceland , Reykjavik , Iceland.
J Nutr Sci ; 5: e10, 2016.
Article en En | MEDLINE | ID: mdl-27066255
Low circulating levels of total 25-hydroxyvitamin D (25(OH)D) have been associated with an increased risk of adverse effects after cardiac surgery. The metabolites, 25(OH)D2 and 25(OH)D3, provide a good index of vitamin D status. In this study, we examined the association between preoperative plasma levels of total 25(OH)D, 25(OH)D2 and 25(OH)D3 and the risk of postoperative atrial fibrillation (POAF) following open heart surgery. The levels of plasma 25(OH)D2 and 25(OH)D3 in 118 patients, who underwent coronary artery bypass grafting and/or valvular surgery, were measured immediately prior to surgery and on postoperative day 3 by liquid chromatography-tandem mass spectrometry. Patients who developed POAF had higher median plasma levels of 25(OH)D2 than those who remained in sinus rhythm (SR) (P = 0·003), but no significant difference was noted in levels of 25(OH)D3 or total 25(OH)D between the two groups (P > 0·05). By univariate analysis, patients with total 25(OH)D and 25(OH)D2 levels above the median had higher frequency of POAF (P < 0·05) and the incidence of POAF increased significantly with each higher quartile of preoperative plasma levels of 25(OH)D2 (P = 0·001), an association that was independent of confounding factors. In both the SR and POAF groups, the median plasma levels of 25(OH)D2, 25(OH)D3 and total 25(OH)D were lower (P < 0·05) on the third postoperative day compared with preoperatively. Our findings demonstrate that higher plasma levels of 25(OH)D2 are associated with increased risk of POAF, while this is not the case for 25(OH)D3 or total 25(OH)D. The reason for these discrepant results is not clear but warrants further study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Incidence_studies / Risk_factors_studies Idioma: En Revista: J Nutr Sci Año: 2016 Tipo del documento: Article País de afiliación: Islandia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Incidence_studies / Risk_factors_studies Idioma: En Revista: J Nutr Sci Año: 2016 Tipo del documento: Article País de afiliación: Islandia Pais de publicación: Reino Unido