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Modification of the Schwartz equations for children increases their accuracy at eGFR > 60 mL/min/1.73 m(2).
Zachwieja, Katarzyna; Korohoda, Przemyslaw; Kwinta-Rybicka, Joanna; Miklaszewska, Monika; Moczulska, Anna; Bugajska, Jolanta; Berska, Joanna; Drozdz, Dorota; Pietrzyk, Jacek A.
Afiliación
  • Zachwieja K; a Department of Pediatric Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
  • Korohoda P; b Faculty Computer Science, Electronics and Telecommunications , AGH University of Science and Technology , Kraków , Poland ;
  • Kwinta-Rybicka J; c Pediatric Nephrology Department , Children's University Hospital of Kraków , Kraków , Poland ;
  • Miklaszewska M; a Department of Pediatric Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
  • Moczulska A; a Department of Pediatric Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
  • Bugajska J; d Clinical Biochemistry Department , Jagiellonian University Medical College , Kraków , Poland.
  • Berska J; d Clinical Biochemistry Department , Jagiellonian University Medical College , Kraków , Poland.
  • Drozdz D; a Department of Pediatric Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
  • Pietrzyk JA; a Department of Pediatric Nephrology , Jagiellonian University Medical College , Kraków , Poland ;
Ren Fail ; 38(5): 787-98, 2016 Jun.
Article en En | MEDLINE | ID: mdl-27056090
AIM: Estimation of eGFR in children with normal kidney function using the Schwartz equations results in underestimating real GFR. MATERIALS AND METHODS: We propose modification of three Schwartz equations - two based on creatinine concentration (eGFRScrBS bedside) and (eGFRScr) and one 3-marker based on creatinine, urea and cystatin C concentrations (eGFRS3M). The iohexol test (reference method) was performed 417 times in 353 children >2 years with mean GFR: 98 ± 31.6 ml/min/1.73m(2). The assessment included also the Filler and Zappitelli equations. The modification was performed using methods: (1) based on equation, eGFRcor = a [eGFR - T] + T, where T = 50, if eGFR > T, and a equals for: eGFRScrBS 1.4043, for eGFRScr 2.0048, for eGFRS3M 1.2951, and (2) based on correction of all coefficients of the original equation. RESULTS: For comparison of all the results and for children with GFR< 60, 60-90, 90-135 and > 135 ml/min/1.73m(2) the correlation coefficient, relative error (RE) and root mean square relative error (RMSRE) was employed and revealed improvement of RE from 25.9 to 6.8 and 3.9% (depending on the correction method) for eGFRScr; from 19 to 8.1 and 3.9% for eGFRScrBS and: from 11.6% to 2.0 and 2.3% for eGFRS3M (respectively). The RMSRE values changed from 30 to 21.3 and 19.8% for eGFRScr, from 25.1 to 21.6 and 19.8% for eGFRScrBS and from 19.1 to 15.8 and 15.3 % for eGFRS3M. CONCLUSIONS: Modifications of Schwartz equations at GFR > 60 ml/min/1.73m(2) significantly improves the accuracy of calculating eGFR. The 3-markers equation is more accurate and should be employed frequently.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Urea / Creatinina / Cistatina C / Tasa de Filtración Glomerular / Riñón Tipo de estudio: Prognostic_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Urea / Creatinina / Cistatina C / Tasa de Filtración Glomerular / Riñón Tipo de estudio: Prognostic_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido