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Gene Expression Profiling of Tuberculous Meningitis Co-infected with HIV.
Kumar, Ghantasala S Sameer; Venugopal, Abhilash K; Kashyap, Manoj Kumar; Raju, Rajesh; Marimuthu, Arivusudar; Palapetta, Shyam Mohan; Subbanayya, Yashwanth; Goel, Renu; Chawla, Ankit; Dikshit, Jyoti Bajpai; Tata, Pramila; Harsha, H C; Maharudraiah, Jagadeesha; Ramachandra, Y L; Satishchandra, Parthasarathy; Prasad, T S Keshava; Pandey, Akhilesh; Mahadevan, Anita; Shankar, S K.
Afiliación
  • Kumar GS; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India; Department of Biotechnology, Kuvempu University, Shimoga 577451, India.
  • Venugopal AK; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India; Department of Biotechnology, Kuvempu University, Shimoga 577451, India; McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of
  • Kashyap MK; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India.
  • Raju R; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India.
  • Marimuthu A; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India.
  • Palapetta SM; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India; Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Pondicherry, 605014, India.
  • Subbanayya Y; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India; Rajiv Gandhi University of Health Sciences, Bangalore 560041, India.
  • Goel R; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India; Department of Biotechnology, Kuvempu University, Shimoga 577451, India.
  • Chawla A; Armed Forces Medical College, Pune-411040, India.
  • Dikshit JB; Strand Life Sciences, Bangalore 560024, Karnataka, India.
  • Tata P; Strand Life Sciences, Bangalore 560024, Karnataka, India.
  • Harsha HC; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India.
  • Maharudraiah J; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India.
  • Ramachandra YL; Department of Biotechnology, Kuvempu University, Shimoga 577451, India.
  • Satishchandra P; Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
  • Prasad TS; Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India; Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Pondicherry, 605014, India; Manipal University, Madhav Nagar, Manipal 576104, India.
  • Pandey A; McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pathology and Oncology, Johns Hopkins University School of M
  • Mahadevan A; Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
  • Shankar SK; Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
J Proteomics Bioinform ; 5(9): 235-244, 2012 Sep.
Article en En | MEDLINE | ID: mdl-27053842
Tuberculous meningitis (TBM) is a fatal form of Mycobacterium tuberculosis infection of the central nervous system (CNS). The similarities in the clinical and radiological findings in TBM cases with or without HIV make the diagnosis very challenging. Identification of genes, which are differentially expressed in brain tissues of HIV positive and HIV negative TBM patients, would enable better understanding of the molecular aspects of the infection and would also serve as an initial platform to evaluate potential biomarkers. Here, we report the identification of 796 differentially regulated genes in brain tissues of TBM patients co-infected with HIV using oligonucleotide DNA microarrays. We also performed immunohistochemical validation and confirmed the abundance of four gene products-glial fibrillary acidic protein (GFAP), serpin peptidase inhibitor, clade A member 3 (SERPINA3), thymidine phosphorylase (TYMP/ECGF1) and heat shock 70 kDa protein 8 (HSPA8). Our study paves the way for understanding the mechanism of TBM in HIV positive patients and for further validation of potential disease biomarkers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Screening_studies Idioma: En Revista: J Proteomics Bioinform Año: 2012 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Screening_studies Idioma: En Revista: J Proteomics Bioinform Año: 2012 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos