Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway.

Heyninck, Karen; Sabbe, Linde; Chirumamilla, Chandra Sekhar; Szarc Vel Szic, Katarzyna; Vander Veken, Pieter; Lemmens, Kristien J A; Lahtela-Kakkonen, Maija; Naulaerts, Stefan; Op de Beeck, Ken; Laukens, Kris; Van Camp, Guy; Weseler, Antje R; Bast, Aalt; Haenen, Guido R M M; Haegeman, Guy; Vanden Berghe, Wim

Heyninck, Karen; Sabbe, Linde; Chirumamilla, Chandra Sekhar; Szarc Vel Szic, Katarzyna; Vander Veken, Pieter; Lemmens, Kristien J A; Lahtela-Kakkonen, Maija; Naulaerts, Stefan; Op de Beeck, Ken; Laukens, Kris; Van Camp, Guy; Weseler, Antje R; Bast, Aalt; Haenen, Guido R M M; Haegeman, Guy; Vanden Berghe, Wim.

Afiliación

Heyninck K; Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Biochemistry and Microbiology, Ghent University, Proeftuinstraat 86, Gent, Belgium. Electronic address: karen.heyninck@ugent.be.
Sabbe L; Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Biochemistry and Microbiology, Ghent University, Proeftuinstraat 86, Gent, Belgium.
Chirumamilla CS; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium.
Szarc Vel Szic K; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium.
Vander Veken P; Laboratory of Medicinal Chemistry, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium.
Lemmens KJA; Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.
Lahtela-Kakkonen M; School of Pharmacy, Pharmaceutical Chemistry, University of Eastern Finland, 70211 Kuopio, Finland.
Naulaerts S; Biomedical Informatics Research Center Antwerp (Biomina), University of Antwerp & University Hospital Antwerp, Campus Middelheim, Middelheimlaan 1, Antwerpen, Belgium; Advanced Database Research and Modelling (ADReM), Department of Mathematics & Computer Sciences, University of Antwerp (UA),
Op de Beeck K; Center of Medical Genetics, Department of Biomedical Sciences, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium; Center for Oncological Research (CORE) Antwerp, Laboratory of Cancer Research and Clinical Oncology, University of Antwerp, Universiteitsplein 1, Wilrijk,
Laukens K; Biomedical Informatics Research Center Antwerp (Biomina), University of Antwerp & University Hospital Antwerp, Campus Middelheim, Middelheimlaan 1, Antwerpen, Belgium; Advanced Database Research and Modelling (ADReM), Department of Mathematics & Computer Sciences, University of Antwerp (UA),
Van Camp G; Center for Oncological Research (CORE) Antwerp, Laboratory of Cancer Research and Clinical Oncology, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium.
Weseler AR; Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.
Bast A; Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.
Haenen GRMM; Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.
Haegeman G; Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Biochemistry and Microbiology, Ghent University, Proeftuinstraat 86, Gent, Belgium.
Vanden Berghe W; Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Biochemistry and Microbiology, Ghent University, Proeftuinstraat 86, Gent, Belgium; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Ant

Biochem Pharmacol ; 109: 48-61, 2016 06 01.

Article en En | MEDLINE | ID: mdl-27045103

Asunto(s)

Regulación de la Expresión Génica/efectos de los fármacos; Hemo-Oxigenasa 1/genética; Proteína 1 Asociada A ECH Tipo Kelch/genética; Factor 2 Relacionado con NF-E2/genética; Witanólidos/farmacología; Células A549; Supervivencia Celular/efectos de los fármacos; Cristalografía por Rayos X; Perfilación de la Expresión Génica; Células HEK293; Hemo-Oxigenasa 1/metabolismo; Células Endoteliales de la Vena Umbilical Humana/citología; Células Endoteliales de la Vena Umbilical Humana/efectos de los fármacos; Células Endoteliales de la Vena Umbilical Humana/metabolismo; Humanos; Hibridomas/citología; Hibridomas/efectos de los fármacos; Hibridomas/metabolismo; Proteína 1 Asociada A ECH Tipo Kelch/química; Proteína 1 Asociada A ECH Tipo Kelch/metabolismo; Fase II de la Desintoxicación Metabólica/genética; Simulación del Acoplamiento Molecular; Factor 2 Relacionado con NF-E2/agonistas; Factor 2 Relacionado con NF-E2/antagonistas & inhibidores; Factor 2 Relacionado con NF-E2/metabolismo; Análisis de Secuencia por Matrices de Oligonucleótidos; Unión Proteica; Dominios Proteicos; Estructura Secundaria de Proteína; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Transducción de Señal; Transcripción Genética; Witanólidos/química

Palabras clave

Antioxidant; Endothelial cell; Molecular pharmacology; Phytochemical; Signal transduction; Transcription regulation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Hemo-Oxigenasa 1 / Factor 2 Relacionado con NF-E2 / Witanólidos / Proteína 1 Asociada A ECH Tipo Kelch Límite: Humans Idioma: En Revista: Biochem Pharmacol Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido

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