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Rifabutin and rifampin resistance levels and associated rpoB mutations in clinical isolates of Mycobacterium tuberculosis complex.
Berrada, Zenda L; Lin, Shou-Yean Grace; Rodwell, Timothy C; Nguyen, Duylinh; Schecter, Gisela F; Pham, Lucy; Janda, J Michael; Elmaraachli, Wael; Catanzaro, Antonino; Desmond, Edward.
Afiliación
  • Berrada ZL; California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA, USA. Electronic address: zberrada@smcgov.org.
  • Lin SY; California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA, USA.
  • Rodwell TC; University of California, San Diego, CA, USA.
  • Nguyen D; California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA, USA.
  • Schecter GF; California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA, USA.
  • Pham L; California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA, USA.
  • Janda JM; California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA, USA.
  • Elmaraachli W; University of California, San Diego, CA, USA.
  • Catanzaro A; University of California, San Diego, CA, USA.
  • Desmond E; California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA, USA.
Diagn Microbiol Infect Dis ; 85(2): 177-81, 2016 Jun.
Article en En | MEDLINE | ID: mdl-27036978
Cross-resistance in rifamycins has been observed in rifampin (RIF)-resistant Mycobacterium tuberculosis complex isolates; some rpoB mutations do not confer broad in vitro rifamycin resistance. We examined 164 isolates, of which 102 were RIF-resistant, for differential resistance between RIF and rifabutin (RFB). A total of 42 unique single mutations or combinations of mutations were detected. The number of unique mutations identified exceeded that reported in any previous study. RFB and RIF MICs up to 8 µg/mL by MGIT 960 were studied; the cut-off values for susceptibility to RIF and RFB were 1 µg/mL and 0.5 µg/mL, respectively. We identified 31 isolates resistant to RIF but susceptible to RFB with the mutations D516V, D516F, 518 deletion, S522L, H526A, H526C, H526G, H526L, and two dual mutations (S522L + K527R and H526S + K527R). Clinical investigations using RFB to treat multidrug-resistant tuberculosis cases harboring those mutations are recommended.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rifampin / Tuberculosis / ARN Polimerasas Dirigidas por ADN / Rifabutina / Mutación Missense / Antibióticos Antituberculosos / Mycobacterium tuberculosis Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rifampin / Tuberculosis / ARN Polimerasas Dirigidas por ADN / Rifabutina / Mutación Missense / Antibióticos Antituberculosos / Mycobacterium tuberculosis Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos