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Suction rectal biopsy yields adequate tissue in children.
Brady, Ann-Christina; Saito, Jacqueline M; Lukas, Karen; Guthrie, Tracey; Utterson, Elizabeth C; White, Frances V; Dillon, Patrick A.
Afiliación
  • Brady AC; Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
  • Saito JM; Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
  • Lukas K; Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
  • Guthrie T; Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
  • Utterson EC; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States.
  • White FV; Division of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
  • Dillon PA; Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States. Electronic address: dillonp@wudosis.wustl.edu.
J Pediatr Surg ; 51(6): 966-9, 2016 Jun.
Article en En | MEDLINE | ID: mdl-27032614
BACKGROUND/PURPOSE: Hirschsprung disease (HD) is diagnosed by rectal biopsy, with suction rectal biopsy (SRB), the preferred technique in neonates. Reported SRB adequacy has varied overall with concern for decreased diagnostic yield in older children. The study aim was to assess SRB adequacy by age in children with the current device used at our institution. METHODS: Following IRB approval, a retrospective cohort of children (1 to 18years) evaluated by SRB for HD was identified through billing records. Data regarding demographics, procedure, results, and complications were collected and analyzed using SPSS. RESULTS: 56 children (median age 3.9years) underwent SRB with an 80.4% overall success rate. Patients older than 5years had 90.5% adequacy rate compared to 74.3% in those younger. Univariate analysis revealed weak association of inadequate specimens with younger age and males, and no association with insurance, race/ethnicity, weight-height or BMI percentile, sedation type, or procedure location. SRB under general anesthesia (GA) had 100% adequacy (n=6). Patients with inadequate initial biopsy achieved diagnosis by SRB with increased sedation (n=5) or full thickness biopsy under GA (n=5). CONCLUSION: With adequacy of 80.4% overall and 90.5% for patients greater than 5years, SRB is effective in evaluating the older child for HD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recto / Biopsia / Enfermedad de Hirschsprung Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Pediatr Surg Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recto / Biopsia / Enfermedad de Hirschsprung Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Pediatr Surg Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos