Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators.

Zhu, Yingdong; Wang, Pei; Zhao, Yantao; Yang, Chun; Clark, Anderson; Leung, TinChung; Chen, Xiaoxin; Sang, Shengmin

Zhu, Yingdong; Wang, Pei; Zhao, Yantao; Yang, Chun; Clark, Anderson; Leung, TinChung; Chen, Xiaoxin; Sang, Shengmin.

Afiliación

Zhu Y; Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA.
Wang P; Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA.
Zhao Y; Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA.
Yang C; Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA; Department of Colorectal Surgery, General Hospital of Ningxia
Clark A; Nutrition Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA.
Leung T; Nutrition Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA.
Chen X; Cancer Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Center University, 700 George Street, Durham, NC 27707, USA.
Sang S; Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA. Electronic address: ssang@ncat.edu.

Free Radic Biol Med ; 95: 243-54, 2016 06.

Article en En | MEDLINE | ID: mdl-27021962

Asunto(s)

Catecoles/administración & dosificación; Proteína 1 Asociada A ECH Tipo Kelch/genética; Factor 2 Relacionado con NF-E2/genética; Estrés Oxidativo/efectos de los fármacos; Animales; Animales Modificados Genéticamente/genética; Antioxidantes/administración & dosificación; Antioxidantes/síntesis química; Catecoles/síntesis química; Cisteína/metabolismo; Gutatión-S-Transferasa pi/genética; Hemo-Oxigenasa 1/genética; Humanos; Estrés Oxidativo/genética; Transducción de Señal/efectos de los fármacos; Relación Estructura-Actividad; Pez Cebra/genética

Palabras clave

Metabolism; Nrf2 activators; Tg(gstp1:GFP) transgenic zebrafish model; [6]-Shogaol derivatives

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catecoles / Estrés Oxidativo / Factor 2 Relacionado con NF-E2 / Proteína 1 Asociada A ECH Tipo Kelch Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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