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Solvates of Dasatinib: Diversity and Isostructurality.
Sarcevica, Inese; Grante, Ilze; Belyakov, Sergey; Rekis, Toms; Berzins, Karlis; Actins, Andris; Orola, Liana.
Afiliación
  • Sarcevica I; Faculty of Chemistry, University of Latvia, Riga LV1013, Latvia.
  • Grante I; Faculty of Chemistry, University of Latvia, Riga LV1013, Latvia.
  • Belyakov S; Latvian Institute of Organic Synthesis, Riga LV1006, Latvia.
  • Rekis T; Faculty of Chemistry, University of Latvia, Riga LV1013, Latvia.
  • Berzins K; Faculty of Chemistry, University of Latvia, Riga LV1013, Latvia.
  • Actins A; Faculty of Chemistry, University of Latvia, Riga LV1013, Latvia.
  • Orola L; Faculty of Chemistry, University of Latvia, Riga LV1013, Latvia. Electronic address: liana.orola@lu.lv.
J Pharm Sci ; 105(4): 1489-95, 2016 Apr.
Article en En | MEDLINE | ID: mdl-27019962
A series of dasatinib crystalline forms were obtained, and a hierarchical cluster analysis of their powder X-ray diffraction patterns was performed. The resulting dendrogram implies 3 structural groups. The crystal structures of several solvates representing 2 of these groups were determined. The crystal structure analysis confirms the isostructurality of solvates within structural group I and suggests a correlation between solvent molecule size and trends in crystal structures within this group. In addition, the formation relationships in 2-solvent media between different dasatinib solvate groups were determined. The formation preference of solvates was found to follow the ranking group I > group III > group II.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dasatinib / Antineoplásicos Idioma: En Revista: J Pharm Sci Año: 2016 Tipo del documento: Article País de afiliación: Letonia Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dasatinib / Antineoplásicos Idioma: En Revista: J Pharm Sci Año: 2016 Tipo del documento: Article País de afiliación: Letonia Pais de publicación: Estados Unidos