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Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyses in a large cohort from the Spanish Society of Rheumatology Lupus Registry.
Pego-Reigosa, José María; Lois-Iglesias, Ana; Rúa-Figueroa, Íñigo; Galindo, María; Calvo-Alén, Jaime; de Uña-Álvarez, Jacobo; Balboa-Barreiro, Vanessa; Ibáñez Ruan, Jesús; Olivé, Alejandro; Rodríguez-Gómez, Manuel; Fernández Nebro, Antonio; Andrés, Mariano; Erausquin, Celia; Tomero, Eva; Horcada Rubio, Loreto; Uriarte Isacelaya, Esther; Freire, Mercedes; Montilla, Carlos; Sánchez-Atrio, Ana I; Santos-Soler, Gregorio; Zea, Antonio; Díez, Elvira; Narváez, Javier; Blanco-Alonso, Ricardo; Silva-Fernández, Lucía; Ruiz-Lucea, María Esther; Fernández-Castro, Mónica; Hernández-Beriain, José Ángel; Gantes-Mora, Marian; Hernández-Cruz, Blanca; Pérez-Venegas, José; Pecondón-Español, Ángela; Marras Fernández-Cid, Carlos; Ibáñez-Barcelo, Mónica; Bonilla, Gema; Torrente-Segarra, Vicenç; Castellví, Iván; Alegre, Juan José; Calvet, Joan; Marenco de la Fuente, José Luis; Raya, Enrique; Vázquez-Rodríguez, Tomás Ramón; Quevedo-Vila, Víctor; Muñoz-Fernández, Santiago; Otón, Teresa; Rahman, Anisur; López-Longo, Francisco Javier.
Afiliación
  • Pego-Reigosa JM; Rheumatology Department, University Hospital Complex of Vigo Rheumatology Department, University Hospital Complex of Vigo.
  • Lois-Iglesias A; Rheumatology Department, University Hospital Complex of Vigo.
  • Rúa-Figueroa Í; Rheumatology Department, University Hospital Complex of Vigo.
  • Galindo M; Rheumatology Department, University Hospital Complex of Vigo.
  • Calvo-Alén J; Rheumatology Department, University Hospital Complex of Vigo.
  • de Uña-Álvarez J; Rheumatology Department, University Hospital Complex of Vigo.
  • Balboa-Barreiro V; Rheumatology Department, University Hospital Complex of Vigo.
  • Ibáñez Ruan J; Rheumatology Department, University Hospital Complex of Vigo.
  • Olivé A; Rheumatology Department, University Hospital Complex of Vigo.
  • Rodríguez-Gómez M; Rheumatology Department, University Hospital Complex of Vigo.
  • Fernández Nebro A; Rheumatology Department, University Hospital Complex of Vigo Rheumatology Department, University Hospital Complex of Vigo.
  • Andrés M; Rheumatology Department, University Hospital Complex of Vigo.
  • Erausquin C; Rheumatology Department, University Hospital Complex of Vigo.
  • Tomero E; Rheumatology Department, University Hospital Complex of Vigo.
  • Horcada Rubio L; Rheumatology Department, University Hospital Complex of Vigo.
  • Uriarte Isacelaya E; Rheumatology Department, University Hospital Complex of Vigo.
  • Freire M; Rheumatology Department, University Hospital Complex of Vigo.
  • Montilla C; Rheumatology Department, University Hospital Complex of Vigo.
  • Sánchez-Atrio AI; Rheumatology Department, University Hospital Complex of Vigo.
  • Santos-Soler G; Rheumatology Department, University Hospital Complex of Vigo.
  • Zea A; Rheumatology Department, University Hospital Complex of Vigo.
  • Díez E; Rheumatology Department, University Hospital Complex of Vigo.
  • Narváez J; Rheumatology Department, University Hospital Complex of Vigo.
  • Blanco-Alonso R; Rheumatology Department, University Hospital Complex of Vigo.
  • Silva-Fernández L; Rheumatology Department, University Hospital Complex of Vigo.
  • Ruiz-Lucea ME; Rheumatology Department, University Hospital Complex of Vigo.
  • Fernández-Castro M; Rheumatology Department, University Hospital Complex of Vigo.
  • Hernández-Beriain JÁ; Rheumatology Department, University Hospital Complex of Vigo.
  • Gantes-Mora M; Rheumatology Department, University Hospital Complex of Vigo.
  • Hernández-Cruz B; Rheumatology Department, University Hospital Complex of Vigo.
  • Pérez-Venegas J; Rheumatology Department, University Hospital Complex of Vigo.
  • Pecondón-Español Á; Rheumatology Department, University Hospital Complex of Vigo.
  • Marras Fernández-Cid C; Rheumatology Department, University Hospital Complex of Vigo.
  • Ibáñez-Barcelo M; Rheumatology Department, University Hospital Complex of Vigo.
  • Bonilla G; Rheumatology Department, University Hospital Complex of Vigo.
  • Torrente-Segarra V; Rheumatology Department, University Hospital Complex of Vigo.
  • Castellví I; Rheumatology Department, University Hospital Complex of Vigo.
  • Alegre JJ; Rheumatology Department, University Hospital Complex of Vigo.
  • Calvet J; Rheumatology Department, University Hospital Complex of Vigo.
  • Marenco de la Fuente JL; Rheumatology Department, University Hospital Complex of Vigo jose.maria.pego.reigosa@sergas.es.
  • Raya E; Rheumatology Department, University Hospital Complex of Vigo.
  • Vázquez-Rodríguez TR; Rheumatology Department, University Hospital Complex of Vigo.
  • Quevedo-Vila V; Rheumatology Department, University Hospital Complex of Vigo.
  • Muñoz-Fernández S; Rheumatology Department, University Hospital Complex of Vigo.
  • Otón T; Rheumatology Department, University Hospital Complex of Vigo.
  • Rahman A; Rheumatology Department, University Hospital Complex of Vigo.
  • López-Longo FJ; Rheumatology Department, University Hospital Complex of Vigo.
Rheumatology (Oxford) ; 55(7): 1243-50, 2016 07.
Article en En | MEDLINE | ID: mdl-27018057
OBJECTIVES: To identify patterns (clusters) of damage manifestations within a large cohort of SLE patients and evaluate the potential association of these clusters with a higher risk of mortality. METHODS: This is a multicentre, descriptive, cross-sectional study of a cohort of 3656 SLE patients from the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics Damage Index. Using cluster analysis, groups of patients with similar patterns of damage manifestations were identified. Then, overall clusters were compared as well as the subgroup of patients within every cluster with disease duration shorter than 5 years. RESULTS: Three damage clusters were identified. Cluster 1 (80.6% of patients) presented a lower amount of individuals with damage (23.2 vs 100% in clusters 2 and 3, P < 0.001). Cluster 2 (11.4% of patients) was characterized by musculoskeletal damage in all patients. Cluster 3 (8.0% of patients) was the only group with cardiovascular damage, and this was present in all patients. The overall mortality rate of patients in clusters 2 and 3 was higher than that in cluster 1 (P < 0.001 for both comparisons) and in patients with disease duration shorter than 5 years as well. CONCLUSION: In a large cohort of SLE patients, cardiovascular and musculoskeletal damage manifestations were the two dominant forms of damage to sort patients into clinically meaningful clusters. Both in early and late stages of the disease, there was a significant association of these clusters with an increased risk of mortality. Physicians should pay special attention to the early prevention of damage in these two systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Enfermedades Cardiovasculares / Enfermedades Musculoesqueléticas / Lupus Eritematoso Sistémico Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Enfermedades Cardiovasculares / Enfermedades Musculoesqueléticas / Lupus Eritematoso Sistémico Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido