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miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence.
Atarod, Sadaf; Ahmed, Mohammed Mahid; Lendrem, Clare; Pearce, Kim Frances; Cope, Wei; Norden, Jean; Wang, Xiao-Nong; Collin, Matthew; Dickinson, Anne Mary.
Afiliación
  • Atarod S; Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
  • Ahmed MM; Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
  • Lendrem C; Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
  • Pearce KF; Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
  • Cope W; Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
  • Norden J; Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
  • Wang XN; Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
  • Collin M; Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
  • Dickinson AM; Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
Front Immunol ; 7: 56, 2016.
Article en En | MEDLINE | ID: mdl-27014257
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality. MicroRNAs (miRNAs) play a significant role in inflammation and have potential as prognostic and diagnostic biomarkers. This study investigated the role of two immune-specific miRNAs (miR-146a and miR-155) as biomarkers for aGVHD incidence in the peripheral blood of allo-HSCT patients prior to disease onset. The study showed that miR-146a and its statistical interaction with miR-155 at day +28 were predictive of aGVHD incidence. Interestingly, the expression levels of miR-146a and miR-155 negatively correlated with the transcription factor, SPI1 (PU.1gene) mRNA expression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Immunol Año: 2016 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Immunol Año: 2016 Tipo del documento: Article Pais de publicación: Suiza