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The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles.
Ziegler, Christopher M; Eisenhauer, Philip; Bruce, Emily A; Weir, Marion E; King, Benjamin R; Klaus, Joseph P; Krementsov, Dimitry N; Shirley, David J; Ballif, Bryan A; Botten, Jason.
Afiliación
  • Ziegler CM; Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, United States of America.
  • Eisenhauer P; Cellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, Burlington, Vermont, United States of America.
  • Bruce EA; Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, United States of America.
  • Weir ME; Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, United States of America.
  • King BR; Department of Biology, University of Vermont, Burlington, Vermont, United States of America.
  • Klaus JP; Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, United States of America.
  • Krementsov DN; Cellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, Burlington, Vermont, United States of America.
  • Shirley DJ; Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, United States of America.
  • Ballif BA; Cellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, Burlington, Vermont, United States of America.
  • Botten J; Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, United States of America.
PLoS Pathog ; 12(3): e1005501, 2016 Mar.
Article en En | MEDLINE | ID: mdl-27010636
Arenaviruses cause severe diseases in humans but establish asymptomatic, lifelong infections in rodent reservoirs. Persistently-infected rodents harbor high levels of defective interfering (DI) particles, which are thought to be important for establishing persistence and mitigating virus-induced cytopathic effect. Little is known about what drives the production of DI particles. We show that neither the PPXY late domain encoded within the lymphocytic choriomeningitis virus (LCMV) matrix protein nor a functional endosomal sorting complex transport (ESCRT) pathway is absolutely required for the generation of standard infectious virus particles. In contrast, DI particle release critically requires the PPXY late domain and is ESCRT-dependent. Additionally, the terminal tyrosine in the PPXY motif is reversibly phosphorylated and our findings indicate that this posttranslational modification may regulate DI particle formation. Thus we have uncovered a new role for the PPXY late domain and a possible mechanism for its regulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virión / Virus Defectuosos / Virus de la Coriomeningitis Linfocítica Límite: Humans Idioma: En Revista: PLoS Pathog Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virión / Virus Defectuosos / Virus de la Coriomeningitis Linfocítica Límite: Humans Idioma: En Revista: PLoS Pathog Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos