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Processing of visual gravitational motion in the peri-sylvian cortex: Evidence from brain-damaged patients.
Maffei, Vincenzo; Mazzarella, Elisabetta; Piras, Fabrizio; Spalletta, Gianfranco; Caltagirone, Carlo; Lacquaniti, Francesco; Daprati, Elena.
Afiliación
  • Maffei V; Laboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy. Electronic address: v.maffei@hsantalucia.it.
  • Mazzarella E; Laboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Piras F; Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; Museo Storico della Fisica e Centro di Studi e Ricerche ''Enrico Fermi'', Rome, Italy.
  • Spalletta G; Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Caltagirone C; Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Lacquaniti F; Laboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Centre of Space BioMedicine, University of Rome Tor Vergata, Rome, Italy.
  • Daprati E; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Centre of Space BioMedicine, University of Rome Tor Vergata, Rome, Italy.
Cortex ; 78: 55-69, 2016 05.
Article en En | MEDLINE | ID: mdl-27007069
Rich behavioral evidence indicates that the brain estimates the visual direction and acceleration of gravity quite accurately, and the underlying mechanisms have begun to be unraveled. While the neuroanatomical substrates of gravity direction processing have been studied extensively in brain-damaged patients, to our knowledge no such study exists for the processing of visual gravitational motion. Here we asked 31 stroke patients to intercept a virtual ball moving along the vertical under either natural gravity or artificial reversed gravity. Twenty-seven of them also aligned a luminous bar to the vertical direction (subjective visual vertical, SVV). Using voxel-based lesion-symptom mapping as well as lesion subtraction analysis, we found that lesions mainly centered on the posterior insula are associated with greater deviations of SVV, consistent with several previous studies. Instead, lesions mainly centered on the parietal operculum decrease the ability to discriminate natural from unnatural gravitational acceleration with a timed motor response in the interception task. Both the posterior insula and the parietal operculum belong to the vestibular cortex, and presumably receive multisensory information about the gravity vector. We speculate that an internal model estimating the effects of gravity on visual objects is constructed by transforming the vestibular estimates of mechanical gravity, which are computed in the brainstem and cerebellum, into internalized estimates of virtual gravity, which are stored in the cortical vestibular network. The present lesion data suggest a specific role for the parietal operculum in detecting the mismatch between predictive signals from the internal model and the online visual signals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Mapeo Encefálico / Corteza Cerebral / Percepción de Movimiento Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Cortex Año: 2016 Tipo del documento: Article Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Mapeo Encefálico / Corteza Cerebral / Percepción de Movimiento Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Cortex Año: 2016 Tipo del documento: Article Pais de publicación: Italia