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Role of glyoxalase I gene polymorphisms in late-onset epilepsy and drug-resistant epilepsy.
Tao, Hua; Si, Ligang; Zhou, Xu; Liu, Zhou; Ma, Zhonghua; Zhou, Haihong; Zhong, Wangtao; Cui, Lili; Zhang, Shuyan; Li, You; Ma, Guoda; Zhao, Jianghao; Huang, Wenhui; Yao, Lifen; Xu, Zhien; Zhao, Bin; Li, Keshen.
Afiliación
  • Tao H; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Si L; Department of Pediatrics, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.
  • Zhou X; Clinical Research Center, Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Liu Z; Institute of Neurology, Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Ma Z; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
  • Zhou H; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Zhong W; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Cui L; Institute of Neurology, Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Zhang S; Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.
  • Li Y; Institute of Neurology, Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Ma G; Institute of Neurology, Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Zhao J; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Huang W; Institute of Neurology, Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Yao L; Department of Pediatrics, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.
  • Xu Z; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
  • Zhao B; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China; Institute of Neurology, Guangdong Medical University, Zhanjiang, Guangdong 524001, China. Electronic address: binzhaoe@163.com.
  • Li K; Institute of Neurology, Guangdong Medical University, Zhanjiang, Guangdong 524001, China. Electronic address: likeshen1971@126.com.
J Neurol Sci ; 363: 200-6, 2016 Apr 15.
Article en En | MEDLINE | ID: mdl-27000251
BACKGROUND: Recent studies indicate that increased expression of glyoxalase I (GLO1) could result in epileptic seizures; thus, this study further explored the association of GLO1 with epilepsy from the perspective of molecular genetics. MATERIAL AND METHODS: GLO1 single nucleotide polymorphisms (SNPs; rs1130534, rs4746 and rs1049346) were investigated in cohort I (the initial samples: 249 cases and 289 controls). A replication study designed to confirm the positive findings in cohort I was performed in cohorts II (the additional samples: 130 cases and 191 controls) and I+II. RESULTS: In cohorts I, II and I+II, the CC genotype at rs1049346 T>C exerts a protective effect against both late-onset epilepsy (odds ratio [OR]=2.437, p=0.013; OR=2.844, p=0.008; OR=2.645, p=0.000, q=0.003, respectively) and drug-resistant epilepsy (DRE) (OR=2.985, p=0.020; OR=2.943, p=0.014; OR=3.049, p=0.001, q=0.006, respectively). Further analyses in cohort I+II indicate that the presence of the TAC/AAT haplotypes (rs1130534-rs4746-rs1049346) may be used as a marker of predisposition to/protection against DRE (p=0.002, q=0.010; p=0.000, q=0.002, respectively). CONCLUSIONS: This study is the first to demonstrate that the GLO1 SNPs are significantly associated with epilepsy. In particular, the rs1049346 T>C SNPs are potentially useful for risk assessment of late-onset epilepsy and DRE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Epilepsia Refractaria / Lactoilglutatión Liasa Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Epilepsia Refractaria / Lactoilglutatión Liasa Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos