Lymphocytic choriomeningitis virus: ways to establish and maintain non-cytolytic persistent infection.
Acta Virol
; 60(1): 15-26, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26982463
Lymphocytic choriomeningitis virus (LCMV) is a prototype virus of the Arenaviridae family that is attracting considerable attention both as an important experimental model system to study acute and persistent viral infections, and as a neglected human pathogen of clinical significance. Notably, LCMV is capable of persisting in an infected host, and escaping the immune system. Here we describe the strategies used by the virus to establish and maintain long-term infection in vitro and/or persistent infection in vivo. We discuss how the viral components (RNA, nucleoprotein, glycoprotein, Z protein) manipulate the host cell machinery to facilitate survival and spread of the virus without disturbing the basal cellular processes. Deep understanding of these strategies is inevitable for the development of approaches towards restricting the virus spread and/or preventing its harmful reactivation. This review summarizes the current status in this area and presents ideas emerging from existing data.
Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Coriomeningitis Linfocítica
/
Virus de la Coriomeningitis Linfocítica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Virol
Año:
2016
Tipo del documento:
Article
Pais de publicación:
Eslovaquia