Your browser doesn't support javascript.
loading
Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis.
Giudice, Aldo; D'Arena, Giovanni; Crispo, Anna; Tecce, Mario Felice; Nocerino, Flavia; Grimaldi, Maria; Rotondo, Emanuela; D'Ursi, Anna Maria; Scrima, Mario; Galdiero, Massimiliano; Ciliberto, Gennaro; Capunzo, Mario; Franci, Gianluigi; Barbieri, Antonio; Bimonte, Sabrina; Montella, Maurizio.
Afiliación
  • Giudice A; Epidemiology Unit, National Cancer Institute of Naples "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
  • D'Arena G; Department of Onco-Hematology, IRCCS, Cancer Referral Center of Basilicata, 85028 Rionero in Vulture, Italy.
  • Crispo A; Epidemiology Unit, National Cancer Institute of Naples "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
  • Tecce MF; Department of Pharmacy, University of Salerno, Fisciano, 84084 Salerno, Italy.
  • Nocerino F; Epidemiology Unit, National Cancer Institute of Naples "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
  • Grimaldi M; Epidemiology Unit, National Cancer Institute of Naples "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
  • Rotondo E; Epidemiology Unit, National Cancer Institute of Naples "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
  • D'Ursi AM; Department of Pharmacy, University of Salerno, Fisciano, 84084 Salerno, Italy.
  • Scrima M; Department of Pharmacy, University of Salerno, Fisciano, 84084 Salerno, Italy.
  • Galdiero M; Department of Experimental Medicine II, University of Naples, 81055 Naples, Italy.
  • Ciliberto G; Scientific Direction, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
  • Capunzo M; Department of Medicine and Surgery, University of Salerno, Baronissi, 84081 Salerno, Italy.
  • Franci G; Department of Experimental Medicine II, University of Naples, 81055 Naples, Italy.
  • Barbieri A; Animal Facility Unit, National Cancer Institute of Naples "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
  • Bimonte S; Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
  • Montella M; Epidemiology Unit, National Cancer Institute of Naples "G. Pascale Foundation", IRCCS, 80131 Naples, Italy.
Oxid Med Cell Longev ; 2016: 6021934, 2016.
Article en En | MEDLINE | ID: mdl-26977250
MicroRNAs are short (21-23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs. Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms. Additionally, recent studies reported that miRNAs can also be encoded by certain single-cell eukaryotes and by viruses. The vast majority of viral miRNAs are encoded by the herpesviruses family. These DNA viruses including Epstein-Barr virus encode their own miRNAs and/or manipulate the expression of cellular miRNAs to facilitate respective infection cycles. Modulation of the control pathways of miRNAs expression is often involved in the promotion of tumorigenesis through a specific cascade of transduction signals. Notably, latent infection with Epstein-Barr virus is considered liable of causing several types of malignancies, including the majority of gastric carcinoma cases detected worldwide. In this review, we describe the role of the Epstein-Barr virus in gastric carcinogenesis, summarizing the functions of the Epstein-Barr virus-encoded viral proteins and related epigenetic alterations as well as the roles of Epstein-Barr virus-encoded and virally modulated cellular miRNAs.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / ARN Viral / Transformación Celular Viral / Herpesvirus Humano 4 / Infecciones por Virus de Epstein-Barr / MicroARNs / Epigénesis Genética Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / ARN Viral / Transformación Celular Viral / Herpesvirus Humano 4 / Infecciones por Virus de Epstein-Barr / MicroARNs / Epigénesis Genética Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos