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History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC).
Amirian, E Susan; Scheurer, Michael E; Zhou, Renke; Wrensch, Margaret R; Armstrong, Georgina N; Lachance, Daniel; Olson, Sara H; Lau, Ching C; Claus, Elizabeth B; Barnholtz-Sloan, Jill S; Il'yasova, Dora; Schildkraut, Joellen; Ali-Osman, Francis; Sadetzki, Siegal; Jenkins, Robert B; Bernstein, Jonine L; Merrell, Ryan T; Davis, Faith G; Lai, Rose; Shete, Sanjay; Amos, Christopher I; Melin, Beatrice S; Bondy, Melissa L.
Afiliación
  • Amirian ES; Department of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
  • Scheurer ME; Department of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
  • Zhou R; Department of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
  • Wrensch MR; Department of Neurological Surgery, University of California, San Francisco, California.
  • Armstrong GN; Department of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
  • Lachance D; Department of Neurology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota.
  • Olson SH; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York.
  • Lau CC; Department of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
  • Claus EB; Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut.
  • Barnholtz-Sloan JS; Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts.
  • Il'yasova D; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
  • Schildkraut J; Department of Epidemiology and Biostatistics, Georgia State University School of Public Health, Atlanta, Georgia.
  • Ali-Osman F; Department of Community and Family Medicine, Cancer Control and Prevention Program, Duke University Medical Center, Durham, North Carolina.
  • Sadetzki S; Department of Community and Family Medicine, Cancer Control and Prevention Program, Duke University Medical Center, Durham, North Carolina.
  • Jenkins RB; Department of Surgery, Duke University Medical Center, Durham, North Carolina.
  • Bernstein JL; Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
  • Merrell RT; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Davis FG; Department of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota.
  • Lai R; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York.
  • Shete S; Department of Neurology, NorthShore University HealthSystem, Evanston, Illinois.
  • Amos CI; Department of Public Health Services, University of Alberta, Edmonton, Alberta, Canada.
  • Melin BS; Departments of Neurology, Neurosurgery, and Preventive Medicine, The University of Southern California Keck School of Medicine, Los Angeles, California.
  • Bondy ML; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Med ; 5(6): 1352-8, 2016 06.
Article en En | MEDLINE | ID: mdl-26972449
Varicella zoster virus (VZV) is a neurotropic α-herpesvirus that causes chickenpox and establishes life-long latency in the cranial nerve and dorsal root ganglia of the host. To date, VZV is the only virus consistently reported to have an inverse association with glioma. The Glioma International Case-Control Study (GICC) is a large, multisite consortium with data on 4533 cases and 4171 controls collected across five countries. Here, we utilized the GICC data to confirm the previously reported associations between history of chickenpox and glioma risk in one of the largest studies to date on this topic. Using two-stage random-effects restricted maximum likelihood modeling, we found that a positive history of chickenpox was associated with a 21% lower glioma risk, adjusting for age and sex (95% confidence intervals (CI): 0.65-0.96). Furthermore, the protective effect of chickenpox was stronger for high-grade gliomas. Our study provides additional evidence that the observed protective effect of chickenpox against glioma is unlikely to be coincidental. Future studies, including meta-analyses of the literature and investigations of the potential biological mechanism, are warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Varicela / Glioma Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Med Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Varicela / Glioma Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Med Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos