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Bone mineral density is associated with left ventricular diastolic function in men with type 2 diabetes.
Wang, R-T; Liu, H-T; Zhao, Y-L; Li, N; Liu, T; Kong, X; Yu, K-J.
Afiliación
  • Wang RT; Department of Intensive Care Unit, Harbin Medical University, the Third Affiliated Hospital, Harbin, Heilongjiang, China.
  • Liu HT; Department of Intensive Care Unit, Harbin Medical University, the Third Affiliated Hospital, Harbin, Heilongjiang, China.
  • Zhao YL; Harbin Medical University (Da Qing), Harbin, Heilongjiang, China.
  • Li N; Department of Cardiology, Harbin Medical University, the Second Affiliated Hospital, Harbin, Heilongjiang, China.
  • Liu T; Division of Hypothalamic Research, UT Southwestern Medical Center, Department of Internal Medicine, 75390 Dallas, TX, USA.
  • Kong X; Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 02215 Boston, MA, USA.
  • Yu KJ; Department of Intensive Care Unit, Harbin Medical University, the Third Affiliated Hospital, Harbin, Heilongjiang, China. Electronic address: kaijiang_yu@yeah.net.
Diabetes Metab ; 42(4): 256-62, 2016 Sep.
Article en En | MEDLINE | ID: mdl-26971836
AIMS: Type 2 diabetes (T2DM) is associated with chronic heart failure and cardiomyopathy. Furthermore, low bone mineral density (BMD) predicts incident heart failure. Abnormal diastolic function reflects early changes in cardiac function and plays a key role in the development of heart failure. The purpose of this study was to investigate the association between BMD with left ventricular (LV) diastolic function in men with T2DM. METHODS: In all, 344 men with T2DM and 331 age-matched control subjects were enrolled. BMD measurements were performed. LV diastolic function and structure were assessed by echocardiographic evaluation. RESULTS: BMD was lower in men with T2DM than in controls. There were significant differences in the level of parameters reflecting cardiac structure and LV diastolic function between two groups. Moreover, LV diastolic function and structure parameters also showed significant differences as BMD reduced in T2DM group. BMD at femoral neck was correlated with LV diastolic function parameters in T2DM after adjusting for confounding factors. Multivariable logistic analysis revealed that osteopenia and osteoporosis were associated with diastolic dysfunction compared to the control in men with T2DM. However, no association between BMD and LV diastolic function was found in subjects without T2DM. CONCLUSION: Osteoporosis may be an independent factor for LV diastolic dysfunction in men with T2DM. Our data suggested that early detection of abnormal BMD should warrant for early search of undetected LV diastolic dysfunction in diabetic men.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Densidad Ósea / Función Ventricular Izquierda / Diabetes Mellitus Tipo 2 Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Diabetes Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Densidad Ósea / Función Ventricular Izquierda / Diabetes Mellitus Tipo 2 Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Diabetes Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia