Asexual blood stage vaccines: from merozoites to peptides.
Trans R Soc Trop Med Hyg
; 83 Suppl: 53-6, 1989.
Article
en En
| MEDLINE
| ID: mdl-2696161
Asexual blood stage proliferation is responsible for the morbidity and mortality associated with malaria infection in man. These developmental stages are therefore obvious targets for the development of malaria vaccines. Several asexual blood stage components have been identified as potential candidates for the development of vaccines and some of them have been shown, following immunization, to induce at least partial protection in a variety of Plasmodium-host combinations. Studies on defined parasite components and on synthetic peptides derived from them have revealed new insights at the molecular level into parasite mechanisms involved in propagation and survival in the infected host, and into the interaction between parasite components and the host immune system. Practical application of these findings is likely to provide the basis for the design of more appropriate antigens for the development of vaccines.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasmodium
/
Vacunas
/
Malaria
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Año:
1989
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Reino Unido