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Methotrexate-associated EBV-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis.
Fujimoto, Masakazu; Kaku, Yo; Yamakawa, Noriyuki; Kawabata, Daisuke; Ohmura, Koichiro; Koyanagi, Itsuko; Mimori, Tsuneyo; Kabashima, Kenji; Haga, Hironori.
Afiliación
  • Fujimoto M; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
  • Kaku Y; Department of Dermatology, Kyoto University Hospital, Kyoto, Japan.
  • Yamakawa N; Department of Rheumatology and Clinical Immunology, Kyoto University Hospital, Kyoto, Japan.
  • Kawabata D; Department of Rheumatology and Clinical Immunology, Kyoto University Hospital, Kyoto, Japan.
  • Ohmura K; Department of Rheumatology and Clinical Immunology, Kyoto University Hospital, Kyoto, Japan.
  • Koyanagi I; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
  • Mimori T; Department of Rheumatology and Clinical Immunology, Kyoto University Hospital, Kyoto, Japan.
  • Kabashima K; Department of Dermatology, Kyoto University Hospital, Kyoto, Japan.
  • Haga H; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
J Cutan Pathol ; 43(6): 520-525, 2016 Jun.
Article en En | MEDLINE | ID: mdl-26955985
Rheumatoid vasculitis (RV) is one of the most serious extra-articular complications of rheumatoid arthritis (RA), generally treated with a high dose of immunosuppressive drugs. Recently, we encountered two cases of ulcerative vasculitis in methotrexate (MTX)-prescribed RA patients, which simulated RV; however, Epstein-Barr virus (EBV)-encoded RNA in situ hybridization on their skin biopsies revealed many EBV-positive lymphocytes (over 50 cells/high-power field) within the vessel walls and perivascular stroma, which led us to the diagnosis of EBV-related vasculitis instead of RV. Subsequently, both ulcers regressed after the discontinuation of MTX and no recurrence was noted during the follow-up period. To prevent unnecessary treatment, EBV-positive vasculitis should be added in the differential diagnosis of lymphocytic vasculitis observed in MTX-administered RA patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Cutan Pathol Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Cutan Pathol Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos