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Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis.
Zhang, Boyang; Montgomery, Miles; Chamberlain, M Dean; Ogawa, Shinichiro; Korolj, Anastasia; Pahnke, Aric; Wells, Laura A; Massé, Stéphane; Kim, Jihye; Reis, Lewis; Momen, Abdul; Nunes, Sara S; Wheeler, Aaron R; Nanthakumar, Kumaraswamy; Keller, Gordon; Sefton, Michael V; Radisic, Milica.
Afiliación
  • Zhang B; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
  • Montgomery M; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
  • Chamberlain MD; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
  • Ogawa S; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
  • Korolj A; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
  • Pahnke A; McEwen Center for Regenerative Medicine, Toronto, Ontario M5G 1L7, Canada.
  • Wells LA; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
  • Massé S; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
  • Kim J; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada.
  • Reis L; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
  • Momen A; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
  • Nunes SS; The Toby Hull Cardiac Fibrillation Management Laboratory, Toronto General Hospital, Toronto, Ontario M5G 2C4, Canada.
  • Wheeler AR; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.
  • Nanthakumar K; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
  • Keller G; Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.
  • Sefton MV; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
  • Radisic M; Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Nat Mater ; 15(6): 669-78, 2016 06.
Article en En | MEDLINE | ID: mdl-26950595
We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable, branched, three-dimensional microchannel network coated with endothelial cells. The design of AngioChip decouples the material choices for the engineered vessel network and for cell seeding in the parenchyma, enabling extensive remodelling while maintaining an open-vessel lumen. The incorporation of nanopores and micro-holes in the vessel walls enhances permeability, and permits intercellular crosstalk and extravasation of monocytes and endothelial cells on biomolecular stimulation. We also show that vascularized hepatic tissues and cardiac tissues engineered by using AngioChips process clinically relevant drugs delivered through the vasculature, and that millimetre-thick cardiac tissues can be engineered in a scalable manner. Moreover, we demonstrate that AngioChip cardiac tissues implanted with direct surgical anastomosis to the femoral vessels of rat hindlimbs establish immediate blood perfusion.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Monocitos / Ingeniería de Tejidos / Andamios del Tejido / Dispositivos Laboratorio en un Chip / Células Endoteliales de la Vena Umbilical Humana / Hígado / Miocardio Límite: Animals / Humans Idioma: En Revista: Nat Mater Asunto de la revista: CIENCIA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Monocitos / Ingeniería de Tejidos / Andamios del Tejido / Dispositivos Laboratorio en un Chip / Células Endoteliales de la Vena Umbilical Humana / Hígado / Miocardio Límite: Animals / Humans Idioma: En Revista: Nat Mater Asunto de la revista: CIENCIA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido