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Functional Magnetic Resonance Imaging of Working Memory and Executive Dysfunction in Systemic Lupus Erythematosus and Antiphospholipid Antibody-Positive Patients.
Kozora, E; Ulug, A M; Erkan, D; Vo, A; Filley, C M; Ramon, G; Burleson, A; Zimmerman, R; Lockshin, M D.
Afiliación
  • Kozora E; National Jewish Health and University of Colorado School of Medicine, Denver, Colorado, and Hospital for Special Surgery and Weill Medical College, Cornell University, New York, New York. kozorae@njhealth.org.
  • Ulug AM; The Feinstein Institute for Medical Research, Manhasset, New York, Hofstra University, Hempstead, New York, Albert Einstein College of Medicine, Bronx, New York, and Institute of Biomedical Engineering, Bogaziçi University, Istanbul, Turkey.
  • Erkan D; Hospital for Special Surgery and Weill Medical College, Cornell University, New York, New York.
  • Vo A; The Feinstein Institute for Medical Research, Manhasset, New York.
  • Filley CM; University of Colorado School of Medicine and Denver Veterans Affairs Medical Center, Denver, Colorado.
  • Ramon G; Hospital for Special Surgery, New York, New York.
  • Burleson A; National Jewish Health, Denver, Colorado.
  • Zimmerman R; Weill Medical College, Cornell University, New York, New York.
  • Lockshin MD; Hospital for Special Surgery and Weill Medical College, Cornell University, New York, New York.
Arthritis Care Res (Hoboken) ; 68(11): 1655-1663, 2016 11.
Article en En | MEDLINE | ID: mdl-26946337
OBJECTIVE: Standardized cognitive tests and functional magnetic resonance imaging (fMRI) studies of systemic lupus erythematosus (SLE) patients demonstrate deficits in working memory and executive function. These neurobehavioral abnormalities are not well studied in antiphospholipid syndrome, which may occur independently of or together with SLE. This study compares an fMRI paradigm involving motor skills, working memory, and executive function in SLE patients without antiphospholipid antibody (aPL) (the SLE group), aPL-positive non-SLE patients (the aPL-positive group), and controls. METHODS: Brain MRI, fMRI, and standardized cognitive assessment results were obtained from 20 SLE, 20 aPL-positive, and 10 healthy female subjects with no history of neuropsychiatric abnormality. RESULTS: Analysis of fMRI data showed no differences in performance across groups on bilateral motor tasks. When analysis of variance was used, significant group differences were found in 2 executive function tasks (word generation and word rhyming) and in a working memory task (N-Back). Patients positive for aPL demonstrated higher activation in bilateral frontal, temporal, and parietal cortices compared to controls during working memory and executive function tasks. SLE patients also demonstrated bilateral frontal and temporal activation during working memory and executive function tasks. CONCLUSION: Compared to controls, both aPL-positive and SLE patients had elevated cortical activation, primarily in the frontal lobes, during tasks involving working memory and executive function. These findings are consistent with cortical overactivation as a compensatory mechanism for early white matter neuropathology in these disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Síndrome Antifosfolípido / Función Ejecutiva / Disfunción Cognitiva / Lupus Eritematoso Sistémico / Memoria a Corto Plazo Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Arthritis Care Res (Hoboken) Asunto de la revista: REUMATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Síndrome Antifosfolípido / Función Ejecutiva / Disfunción Cognitiva / Lupus Eritematoso Sistémico / Memoria a Corto Plazo Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Arthritis Care Res (Hoboken) Asunto de la revista: REUMATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos