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Neuroprotective effects of ginsenosides on neural progenitor cells against oxidative injury.
Ye, Jun; Yao, Jian-Ping; Wang, Xu; Zheng, Minying; Li, Peng; He, Chengwei; Wan, Jian-Bo; Yao, Xiaoli; Su, Huanxing.
Afiliación
  • Ye J; Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zheijiang 310016, P.R. China.
  • Yao JP; Department of Cardiac Surgery II, The First Affiliated Hospital Sun Yat­Sen University, Guangzhou, Guangdong 510080, P.R. China.
  • Wang X; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, P.R. China.
  • Zheng M; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat­Sen University, Guangzhou, Guangdong 510080, P.R. China.
  • Li P; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, P.R. China.
  • He C; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, P.R. China.
  • Wan JB; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, P.R. China.
  • Yao X; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat­Sen University, Guangzhou, Guangdong 510080, P.R. China.
  • Su H; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, P.R. China.
Mol Med Rep ; 13(4): 3083-91, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26935530
Ginsenosides exhibit various neuroprotective effects against oxidative stress. However, which ginsenoside provides optimal effects for the treatment of neurological disorders as a potent antioxidant remains to be elucidated. Therefore, the present study investigated and compared the neuroprotective effects of the Rb1, Rd, Rg1 and Re ginsenosides on neural progenitor cells (NPCs) following tert-Butylhydroperoxide (t-BHP)-induced oxidative injury. Primary rat embryonic cortical NPCs were prepared from E14.5 embryos of Sprague-Dawley rats. The oxidative injury model was established with t­BHP. A lactate dehydrogenase assay and terminal deoxynucleotidyl transferase dUTP nick­end labeling staining were used to measure the viability of the NPCs pre­treated with ginsenosides under oxidative stress. Reverse transcription­quantitative polymerase chain reaction analysis was used to determine the activation of intracellular signaling pathways triggered by the pretreatment of ginsenosides. Among the four ginsenosides, only Rb1 attenuated t­BHP toxicity in the NPCs, and the nuclear factor (erythroizd­derived 2)­like 2/heme oxygenase­1 pathway was found to be key in the intracellular defense against oxidative stress. The present study demonstrated the anti-oxidative effects of ginsenoside Rb1 on NPCs, and suggested that Rb1 may offer potential as a potent antioxidant for the treatment of neurological disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Fármacos Neuroprotectores / Ginsenósidos / Células-Madre Neurales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Med Rep Año: 2016 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Fármacos Neuroprotectores / Ginsenósidos / Células-Madre Neurales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Med Rep Año: 2016 Tipo del documento: Article Pais de publicación: Grecia