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Stochastic resonance in the synaptic transmission between hair cells and vestibular primary afferents in development.
Flores, A; Manilla, S; Huidobro, N; De la Torre-Valdovinos, B; Kristeva, R; Mendez-Balbuena, I; Galindo, F; Treviño, M; Manjarrez, E.
Afiliación
  • Flores A; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Mexico. Electronic address: amira.flores@correo.buap.mx.
  • Manilla S; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Mexico.
  • Huidobro N; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Mexico.
  • De la Torre-Valdovinos B; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Mexico.
  • Kristeva R; Department of Neurology, University of Freiburg, Breisacherstraße 64, 79106 Freiburg, Germany.
  • Mendez-Balbuena I; Facultad de Psicología, Benemérita Universidad Autónoma de Puebla, Mexico.
  • Galindo F; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Mexico.
  • Treviño M; Laboratorio de Plasticidad Cortical y Aprendizaje Perceptual, Instituto de Neurociencias, Universidad de Guadalajara, Mexico.
  • Manjarrez E; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Mexico. Electronic address: eliasmanjarrez@gmail.com.
Neuroscience ; 322: 416-29, 2016 May 13.
Article en En | MEDLINE | ID: mdl-26926966
The stochastic resonance (SR) is a phenomenon of nonlinear systems in which the addition of an intermediate level of noise improves the response of such system. Although SR has been studied in isolated hair cells and in the bullfrog sacculus, the occurrence of this phenomenon in the vestibular system in development is unknown. The purpose of the present study was to explore for the existence of SR via natural mechanical-stimulation in the hair cell-vestibular primary afferent transmission. In vitro experiments were performed on the posterior semicircular canal of the chicken inner ear during development. Our experiments showed that the signal-to-noise ratio of the afferent multiunit activity from E15 to P5 stages of development exhibited the SR phenomenon, which was characterized by an inverted U-like response as a function of the input noise level. The inverted U-like graphs of SR acquired their higher amplitude after the post-hatching stage of development. Blockage of the synaptic transmission with selective antagonists of the NMDA and AMPA/Kainate receptors abolished the SR of the afferent multiunit activity. Furthermore, computer simulations on a model of the hair cell - primary afferent synapse qualitatively reproduced this SR behavior and provided a possible explanation of how and where the SR could occur. These results demonstrate that a particular level of mechanical noise on the semicircular canals can improve the performance of the vestibular system in their peripheral sensory processing even during embryonic stages of development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canales Semicirculares / Células Ciliadas Vestibulares / Transmisión Sináptica Límite: Animals Idioma: En Revista: Neuroscience Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canales Semicirculares / Células Ciliadas Vestibulares / Transmisión Sináptica Límite: Animals Idioma: En Revista: Neuroscience Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos