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Intensive statin therapy, used alone or in combination with ezetimibe, improves homocysteine level and lipid peroxidation to a similar degree in patients with coronary artery diseases.
Pytel, Edyta; Jackowska, Paulina; Chwatko, Grazyna; Olszewska-Banaszczyk, Malgorzata; Koter-Michalak, Maria; Kubalczyk, Pawel; Broncel, Marlena.
Afiliación
  • Pytel E; Department of Environment Pollution Biophysics, Faculty of Biology and Environmental Protection, University of Lódz, Lódz, Poland. Electronic address: epytel@biol.uni.lodz.pl.
  • Jackowska P; Department of Internal Diseases and Clinical Pharmacology, Medical University of Lódz, Lódz, Poland.
  • Chwatko G; Department of Environmental Chemistry, Faculty of Chemistry, University of Lódz, Lódz, Poland.
  • Olszewska-Banaszczyk M; Department of Internal Diseases and Clinical Pharmacology, Medical University of Lódz, Lódz, Poland.
  • Koter-Michalak M; Department of Environment Pollution Biophysics, Faculty of Biology and Environmental Protection, University of Lódz, Lódz, Poland.
  • Kubalczyk P; Department of Environmental Chemistry, Faculty of Chemistry, University of Lódz, Lódz, Poland.
  • Broncel M; Department of Internal Diseases and Clinical Pharmacology, Medical University of Lódz, Lódz, Poland.
Pharmacol Rep ; 68(2): 344-8, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26922537
BACKGROUND: Increase in the concentration of homocysteine is one of the risks of cardiovascular diseases. Coronary artery disease accompanied the increase of LDL cholesterol level and hipolipemic drugs are used in such treatments. Also these drugs have pleiotropic effects, which are not greatly known. The aim of that study is to compare the effect of three different hipolipemic therapies (rosuvastatin 15mg/d; atorvastatin 40mg/d; atorvastatin+ezetymibe 10mg/d+10mg/d) depending upon the concentration of homocysteine and lipid peroxidation in plasma of CAD patients with non-target LDL-cholesterol level. METHODS AND RESULTS: The study involved 30 healthy subjects as well as 30 patients with angiographically confirmed coronary artery disease who despite at least 6 months hypolipidemic treatment did not achieve LDL-C <70mg/dl. The following parameters studied included homocysteine level, lipid peroxidation in plasma and lipidogram parameters. Our study showed increase of homocysteine level, lipid peroxidation in plasma, LDL-C concentration and total cholesterol level. After six months therapy, the following changes were observed in comparison to the values before therapy: decrease of homocysteine level in plasma - R15 20%, A40 26% and A+E 28%; decrease of lipid peroxidation in plasma - R15 31%, A40 27% and A+E 32%; decrease of LDL-C cholesterol level - R15 18%; A40 17% and A+E 33% and decrease of total cholesterol level - R15 9%, A40 15% and A+E 17%. CONCLUSION: Our results suggest that intensive lipid-lowering therapy has a beneficial effect on certain parameters of the blood of CAD patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Peroxidación de Lípido / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Quimioterapia Combinada / Ezetimiba / Homocisteína Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pharmacol Rep Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Suiza
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Peroxidación de Lípido / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Quimioterapia Combinada / Ezetimiba / Homocisteína Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pharmacol Rep Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Suiza