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Alterations of soluble TWEAK and CD163 concentrations in patients with chronic heart failure.
Ptaszynska-Kopczynska, Katarzyna; Marcinkiewicz-Siemion, Marta; Lisowska, Anna; Waszkiewicz, Ewa; Witkowski, Marcin; Jasiewicz, Malgorzata; Miklasz, Paula; Jakim, Piotr; Galar, Bogdan; Musial, Wlodzimierz Jerzy; Kaminski, Karol Adam.
Afiliación
  • Ptaszynska-Kopczynska K; Department of Cardiology, Medical University of Bialystok, Poland.
  • Marcinkiewicz-Siemion M; Department of Cardiology, Medical University of Bialystok, Poland.
  • Lisowska A; Department of Cardiology, Medical University of Bialystok, Poland.
  • Waszkiewicz E; Department of Cardiology, Medical University of Bialystok, Poland.
  • Witkowski M; Department of Cardiology, Medical University of Bialystok, Poland.
  • Jasiewicz M; Department of Cardiology, Medical University of Bialystok, Poland.
  • Miklasz P; Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Poland.
  • Jakim P; Department of Cardiology, Internal Affair and Administration Ministry Hospital, Bialystok, Poland.
  • Galar B; Department of Cardiology, Internal Affair and Administration Ministry Hospital, Bialystok, Poland.
  • Musial WJ; Department of Cardiology, Medical University of Bialystok, Poland.
  • Kaminski KA; Department of Cardiology, Medical University of Bialystok, Poland; Department of Community Medicine and Civilization Disease Prevention, Medical University of Bialystok, Poland. Electronic address: fizklin@wp.pl.
Cytokine ; 80: 7-12, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26916171
UNLABELLED: Inflammatory activation plays a pivotal role in chronic heart failure with reduced ejection fraction (HF-REF). A novel mediator from TNF family: soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) along its soluble decoy receptor CD163 (sCD163) recently has been investigated in other cardiovascular pathologies. We aimed to evaluate sTWEAK and sCD163 concentrations in HF-REF patients. The study enrolled 79 patients with stable HF-REF, EF < 35%. The control population without history of heart failure included two groups: 26 comorbidities matched patients and 27 healthy volunteers. sTWEAK and sCD163 serum concentrations were determined using ELISA kits. Univariate and multivariate analysis was performed to assess variables affecting concentration of sTWEAK and sCD163. HF-REF patients were characterized by higher sTWEAK (median 374 IQR: 321-429 vs 201 IQR: 145-412pg/ml, P=0.005), sCD163 (median 744 IQR: 570-1068 vs 584 IQR: 483-665pg/ml, P=0.03) concentrations and sTWEAK/sCD163 ratio (median 0.53 IQR: 0.32-0.7 vs 0.3 IQR: 0.22-0.37, P=0.001) comparing to healthy volunteers. Comparing to comorbidities matched controls, HF-REF patients had lower sTWEAK levels (median 374 IQR: 321-429 vs 524 IQR: 384-652pg/ml; P=0.002), while sCD163 and sTWEAK/sCD163 ratio didn't differ. Concentration of sTWEAK in HF-REF was affected by white blood cell count and aspirin intake, while sCD163 by exercise capacity, LV diastolic volume, CRP and presence of arterial hypertension. CONCLUSIONS: HF-REF patients present increased sTWEAK and sCD163 levels as well as sTWEAK/sCD163 ratio when compared to healthy subjects, however CHF itself appears to be associated with down-regulation of sTWEAK.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos de Diferenciación Mielomonocítica / Antígenos CD / Receptores de Superficie Celular / Factores de Necrosis Tumoral / Insuficiencia Cardíaca Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos de Diferenciación Mielomonocítica / Antígenos CD / Receptores de Superficie Celular / Factores de Necrosis Tumoral / Insuficiencia Cardíaca Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido