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Dopamine Regulates Aversive Contextual Learning and Associated In Vivo Synaptic Plasticity in the Hippocampus.
Broussard, John I; Yang, Kechun; Levine, Amber T; Tsetsenis, Theodoros; Jenson, Daniel; Cao, Fei; Garcia, Isabella; Arenkiel, Benjamin R; Zhou, Fu-Ming; De Biasi, Mariella; Dani, John A.
Afiliación
  • Broussard JI; Department of Neuroscience, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.
  • Yang K; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, Philadelphia, PA 19104, USA.
  • Levine AT; Department of Neuroscience, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.
  • Tsetsenis T; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, Philadelphia, PA 19104, USA.
  • Jenson D; Department of Neuroscience, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.
  • Cao F; Department of Neuroscience, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.
  • Garcia I; Program in Developmental Biology , Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.
  • Arenkiel BR; Program in Developmental Biology , Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.
  • Zhou FM; Department of Pharmacology, University of Tennessee, Memphis, TN 38163 USA.
  • De Biasi M; Department of Psychiatry, Mahoney Institute for Neurosciences, Perelman School for Medicine, Philadelphia, PA 19104, USA.
  • Dani JA; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, Philadelphia, PA 19104, USA. Electronic address: johndani@upenn.edu.
Cell Rep ; 14(8): 1930-9, 2016 Mar 01.
Article en En | MEDLINE | ID: mdl-26904943
Dopamine release during reward-driven behaviors influences synaptic plasticity. However, dopamine innervation and release in the hippocampus and its role during aversive behaviors are controversial. Here, we show that in vivo hippocampal synaptic plasticity in the CA3-CA1 circuit underlies contextual learning during inhibitory avoidance (IA) training. Immunohistochemistry and molecular techniques verified sparse dopaminergic innervation of the hippocampus from the midbrain. The long-term synaptic potentiation (LTP) underlying the learning of IA was assessed with a D1-like dopamine receptor agonist or antagonist in ex vivo hippocampal slices and in vivo in freely moving mice. Inhibition of D1-like dopamine receptors impaired memory of the IA task and prevented the training-induced enhancement of both ex vivo and in vivo LTP induction. The results indicate that dopamine-receptor signaling during an aversive contextual task regulates aversive memory retention and regulates associated synaptic mechanisms in the hippocampus that likely underlie learning.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacción de Prevención / Dopamina / Potenciación a Largo Plazo / Región CA1 Hipocampal / Memoria a Largo Plazo / Aprendizaje Tipo de estudio: Risk_factors_studies Idioma: En Revista: Cell Rep Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacción de Prevención / Dopamina / Potenciación a Largo Plazo / Región CA1 Hipocampal / Memoria a Largo Plazo / Aprendizaje Tipo de estudio: Risk_factors_studies Idioma: En Revista: Cell Rep Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos