Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.

Wangpu, Xiongzhi; Lu, Jiaoyang; Xi, Ruxing; Yue, Fei; Sahni, Sumit; Park, Kyung Chan; Menezes, Sharleen; Huang, Michael L H; Zheng, Minhua; Kovacevic, Zaklina; Richardson, Des R

Wangpu, Xiongzhi; Lu, Jiaoyang; Xi, Ruxing; Yue, Fei; Sahni, Sumit; Park, Kyung Chan; Menezes, Sharleen; Huang, Michael L H; Zheng, Minhua; Kovacevic, Zaklina; Richardson, Des R.

Afiliación

Wangpu X; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C
Lu J; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C
Xi R; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C
Yue F; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C
Sahni S; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C
Park KC; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C
Menezes S; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C
Huang ML; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C
Zheng M; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C
Kovacevic Z; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C
Richardson DR; Department of General Surgery; Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.W., J.L., F.Y., M.Z.); Department of Pathology and Bosch Institute, University of Sydney, New South Wales, Australia (X.W., R.X., S.S., K.C

Mol Pharmacol ; 89(5): 521-40, 2016 May.

Article en En | MEDLINE | ID: mdl-26895766

Asunto(s)

Proteínas de Ciclo Celular/metabolismo; Neoplasias del Colon/metabolismo; Quinasa 1 de Adhesión Focal/metabolismo; Péptidos y Proteínas de Señalización Intracelular/metabolismo; Paxillin/metabolismo; Neoplasias de la Próstata/metabolismo; Procesamiento Proteico-Postraduccional; Transducción de Señal; Antineoplásicos/farmacología; Adhesión Celular/efectos de los fármacos; Proteínas de Ciclo Celular/antagonistas & inhibidores; Proteínas de Ciclo Celular/genética; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Colágeno/metabolismo; Neoplasias del Colon/tratamiento farmacológico; Neoplasias del Colon/patología; Activación Enzimática/efectos de los fármacos; Quinasa 1 de Adhesión Focal/antagonistas & inhibidores; Quinasa 1 de Adhesión Focal/química; Quinasa 1 de Adhesión Focal/genética; Adhesiones Focales/efectos de los fármacos; Adhesiones Focales/metabolismo; Adhesiones Focales/patología; Humanos; Péptidos y Proteínas de Señalización Intracelular/antagonistas & inhibidores; Péptidos y Proteínas de Señalización Intracelular/genética; Masculino; Proteínas de Neoplasias/agonistas; Proteínas de Neoplasias/antagonistas & inhibidores; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo; Paxillin/agonistas; Paxillin/antagonistas & inhibidores; Fosforilación/efectos de los fármacos; Neoplasias de la Próstata/tratamiento farmacológico; Neoplasias de la Próstata/patología; Inhibidores de Proteínas Quinasas/farmacología; Procesamiento Proteico-Postraduccional/efectos de los fármacos; Piridinas/farmacología; Interferencia de ARN; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Transducción de Señal/efectos de los fármacos; Tiosemicarbazonas/farmacología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Transducción de Señal / Procesamiento Proteico-Postraduccional / Neoplasias del Colon / Proteínas de Ciclo Celular / Péptidos y Proteínas de Señalización Intracelular / Quinasa 1 de Adhesión Focal / Paxillin Idioma: En Revista: Mol Pharmacol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos

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