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Benefits of the Nephros Dual Stage Ultrafilter in Chronic Hemodialysis Patients: Evidence for Improved ESA Responsiveness.
Valeri, Anthony; Lee, Bobby; Duffy, John; Ferrer, Robin; Vilotta, Ronald.
Afiliación
  • Valeri A; Department of Medicine, New York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y., USA.
  • Lee B; Department of Pharmacy, New York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y., USA.
  • Duffy J; Department of Biomedical Engineering, New York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y., USA.
  • Ferrer R; Department of Nursing, New York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y., USA.
  • Vilotta R; Department of Nursing, New York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y., USA.
Case Rep Nephrol Dial ; 6(1): 8-13, 2016.
Article en En | MEDLINE | ID: mdl-26889475
Installation of the Nephros Dual Stage Ultrafilter (DSU) added to a conventional hemodialysis unit to achieve ultrapure dialysate was tested in a group of 23 stable outpatients on chronic hemodialysis. Comparing the 6-month period prior to the installation of the filters (as baseline) to the 6-month period after the installation of the filters, we found a significant 40% reduction in the darbepoetin dose needed to maintain a stable hemoglobin level (p < 0.001). In addition, surrogate inflammatory markers, WBC count and serum albumin level, showed small but statistically significant improvements (p = 0.008 and p = 0.042, respectively). In conclusion, the use of the Nephros DSU to further reduce endotoxin exposure in chronic hemodialysis patients can result in improved erythropoiesis-stimulating agent (ESA) responsiveness and a lower ESA dose.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Case Rep Nephrol Dial Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Case Rep Nephrol Dial Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza