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Longitudinal functional and NMR assessment of upper limbs in Duchenne muscular dystrophy.
Hogrel, Jean-Yves; Wary, Claire; Moraux, Amélie; Azzabou, Noura; Decostre, Valérie; Ollivier, Gwenn; Canal, Aurélie; Lilien, Charlotte; Ledoux, Isabelle; Annoussamy, Mélanie; Reguiba, Nacera; Gidaro, Teresa; Le Moing, Anne Gaelle; Cardas, Ruxandra; Voit, Thomas; Carlier, Pierre G; Servais, Laurent.
Afiliación
  • Hogrel JY; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France. jy.hogrel@institut-myologie.org.
  • Wary C; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Moraux A; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Azzabou N; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Decostre V; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Ollivier G; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Canal A; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Lilien C; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Ledoux I; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Annoussamy M; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Reguiba N; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Gidaro T; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Le Moing AG; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Cardas R; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Voit T; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Carlier PG; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
  • Servais L; From the Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
Neurology ; 86(11): 1022-30, 2016 Mar 15.
Article en En | MEDLINE | ID: mdl-26888987
OBJECTIVE: To explore the value of nuclear magnetic resonance (NMR) and functional assessments for follow-up of ambulatory and nonambulatory patients with Duchenne muscular dystrophy (DMD). METHODS: Twenty-five 53-skippable patients with DMD were included in this study; 15 were nonambulatory at baseline. All patients underwent clinical and functional assessments every 6 months using the Motor Function Measure (MFM), hand grip and key pinch strength, MoviPlate, and NMR spectroscopy and imaging studies. RESULTS: Upper limb distal strength decreased in nonambulatory patients over the period of 1 year; ambulatory patients showed improvement during the same period. The same applied for several NMRS indices, such as phosphocreatine/adenosine triphosphate, which decreased in older patients but increased in younger ambulatory patients. Fat infiltration in the upper limbs increased linearly with age. Almost all NMR and functional assessment results correlated. CONCLUSIONS: Our results underscore complementarity of functional and NMR assessments in patients with DMD. Sensitivity to change of various indices may differ according to disease stage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectroscopía de Resonancia Magnética / Distrofia Muscular de Duchenne / Extremidad Superior Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Child / Humans / Male Idioma: En Revista: Neurology Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectroscopía de Resonancia Magnética / Distrofia Muscular de Duchenne / Extremidad Superior Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Child / Humans / Male Idioma: En Revista: Neurology Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos