Your browser doesn't support javascript.
loading
Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome.
Zhang, Yong; Li, Xiru; Grailer, Jamison J; Wang, Na; Wang, Mingming; Yao, Jianfei; Zhong, Rui; Gao, George F; Ward, Peter A; Tan, Dun-Xian; Li, Xiangdong.
Afiliación
  • Zhang Y; State Key Laboratory of the Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
  • Li X; Department of General Surgery, The 301th Hospital of PLA, Beijing, China.
  • Grailer JJ; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Wang N; State Key Laboratory of the Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
  • Wang M; State Key Laboratory of the Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
  • Yao J; State Key Laboratory of the Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
  • Zhong R; State Key Laboratory of the Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
  • Gao GF; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences Beijing, China.
  • Ward PA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Tan DX; The University of Texas Health Science Center at San Antonio Department of Cellular and Structural Biology, San Antonio, TX, USA.
  • Li X; State Key Laboratory of the Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
J Pineal Res ; 60(4): 405-14, 2016 May.
Article en En | MEDLINE | ID: mdl-26888116
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically severe respiratory disorders, and there are currently no Food and Drug Administration-approved drug therapies. Melatonin is a well-known anti-inflammatory molecule, which has proven to be effective in ALI induced by many conditions. Emerging studies suggest that the NLRP3 inflammasome plays a critical role during ALI. How melatonin directly blocks activation of the NLRP3 inflammasome in ALI remains unclear. In this study, using an LPS-induced ALI mouse model, we found intratracheal (i.t.) administration of melatonin markedly reduced the pulmonary injury and decreased the infiltration of macrophages and neutrophils into lung. During ALI, the NLRP3 inflammasome is significantly activated with a large amount of IL-1ß and the activated caspase-1 occurring in the lung. Melatonin inhibits the activation of the NLRP3 inflammasome by both suppressing the release of extracellular histones and directly blocking histone-induced NLRP3 inflammasome activation. Notably, i.t. route of melatonin administration opens a more efficient therapeutic approach for treating ALI.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesión Pulmonar Aguda / Inflamasomas / Proteína con Dominio Pirina 3 de la Familia NLR / Melatonina / Antiinflamatorios Límite: Animals Idioma: En Revista: J Pineal Res Asunto de la revista: ENDOCRINOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesión Pulmonar Aguda / Inflamasomas / Proteína con Dominio Pirina 3 de la Familia NLR / Melatonina / Antiinflamatorios Límite: Animals Idioma: En Revista: J Pineal Res Asunto de la revista: ENDOCRINOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido