Mechanisms of uterine estrogen signaling during early pregnancy in mice: an update.

Robertshaw, I; Bian, F; Das, S K

Robertshaw, I; Bian, F; Das, S K.

Afiliación

Robertshaw I; Department of Obstetrics and GynecologyUniversity of Cincinnati, West Chester, Ohio, USA Division of Reproductive SciencesCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Bian F; Division of Reproductive SciencesCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Perinatal InstituteCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Das SK; Division of Reproductive SciencesCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Perinatal InstituteCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Department of PediatricsUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA sanjoy.das@cchmc.org.

J Mol Endocrinol ; 56(3): R127-38, 2016 04.

Article en En | MEDLINE | ID: mdl-26887389

RESUMEN

Adherence of an embryo to the uterus represents the most critical step of the reproductive process. Implantation is a synchronized event between the blastocyst and the uterine luminal epithelium, leading to structural and functional changes for further embryonic growth and development. The milieu comprising the complex process of implantation is mediated by estrogen through diverse but interdependent signaling pathways. Mouse models have demonstrated the relevance of the expression of estrogen-modulated paracrine factors to uterine receptivity and implantation window. More importantly, some factors seem to serve as molecular links between different estrogen pathways, promoting cell growth, acting as molecular chaperones, or amplifying estrogenic effects. Abnormal expression of these factors can lead to implantation failure and infertility. This review provides an overview of several well-characterized signaling pathways that elucidates the molecular cross talk involved in the uterus during early pregnancy.

Asunto(s)

Estrógenos/metabolismo; Transducción de Señal; Útero/metabolismo; Animales; Biomarcadores; Factor de Transcripción COUP II/metabolismo; Implantación del Embrión/genética; Receptor alfa de Estrógeno/química; Receptor alfa de Estrógeno/metabolismo; Femenino; Regulación del Desarrollo de la Expresión Génica; Edad Gestacional; Proteínas Hedgehog/metabolismo; Péptidos y Proteínas de Señalización Intercelular/metabolismo; Factor Inhibidor de Leucemia/metabolismo; Ratones; Membrana Mucosa/metabolismo; Embarazo; Dominios y Motivos de Interacción de Proteínas; Receptores de Estrógenos/química; Receptores de Estrógenos/metabolismo; Células del Estroma/metabolismo

Palabras clave

estrogen; implantation; pregnancy; signaling; uterus

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Útero / Transducción de Señal / Estrógenos Tipo de estudio: Prognostic_studies Límite: Animals / Pregnancy Idioma: En Revista: J Mol Endocrinol Asunto de la revista: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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